Evidence map›Paper›PMID 39434513›Full record

ArticleJournal of applied biomedicine2024

In vitro biological activities of Calamintha nepeta L. aqueous extracts.

Nadia Salhi, Dorien Deluyker, Virginie Bito, Abdelhamid Zaid, Lhoussaine El Rhaffari

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of applied biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nadia SalhiMoulay Ismail University, Faculty of Sciences, Laboratory of BioActives Health and Environment, Meknes, Morocco.
Dorien DeluykerBiomedical Research Institute, UHasselt, Cardio & Organ Systems (COST), Agoralaan, 3590 Diepenbeek, Belgium.
Virginie BitoBiomedical Research Institute, UHasselt, Cardio & Organ Systems (COST), Agoralaan, 3590 Diepenbeek, Belgium.
Abdelhamid ZaidMoulay Ismail University, Faculty of Sciences, Laboratory of BioActives Health and Environment, Meknes, Morocco.
Lhoussaine El RhaffariMoulay Ismail University, Faculty of Sciences, Laboratory of BioActives Health and Environment, Meknes, Morocco.

Funding

Institutional University Cooperation MA2017IUC038A104
6 · The paper itself

Abstract

aimThis study aimed to investigate the phenolic composition, antioxidant capacity, and toxicity of aqueous extracts of Calamintha nepeta L. leaves and their potential vasorelaxant effects.

methodsAqueous extracts of Calamintha nepeta L. were prepared by three extraction methods: decoction, infusion, and maceration. The total phenolic contents of the extracts and their antioxidant properties were investigated. The toxicity was evaluated by Artemia salina lethality bioassay. The decoction extract was analyzed by HPLC for its chemical profile and was also used to evaluate the vasorelaxant effect on thoracic aortic rings isolated from healthy Sprague Dawley rats. Pre-contraction was induced by phenylephrine, followed by cumulative doses of the extract (0.001 up to 250 µg/ml).

resultsAqueous extracts of Calamintha nepeta L. showed noticeable radical scavenging and chelating activities. However, the decoction extract exhibited the most powerful antioxidant capacity. No toxicity was recorded for the extracts obtained by decoction and infusion. Caffeic acid, quercetin, and rosmarinic acid were the main identified compounds. Notably, the aqueous extract obtained by decoction induced significant relaxation in endothelium-intact aortic rings at lower concentrations, and at higher concentrations in denuded aortic rings.

conclusionThis study reveals that Calamintha nepeta L. extracted with a decoction method possesses potent antioxidant capacity and has an endothelium-dependent vasorelaxant effect.

Indexed as

AntioxidantsPlant ExtractsRats, Sprague-DawleyVasodilator AgentsAnimalsAorta, ThoracicArtemiaMalePhenolsPlant LeavesRatsAntioxidantsPhenolsPlant ExtractsVasodilator AgentsAntioxidant activityAqueous extractsCalamintha nepeta L.PolyphenolsVasorelaxation

Identifiers

PMID39434513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.