Evidence map›Paper›PMID 39434457›Full record

ArticleBritish journal of haematology2025

Avatrombopag for the treatment of patients with chemotherapy-induced thrombocytopenia: A case series.

Robert Galamaga, Stephanie Johnston, Cassaundra Acosta

Abstract readCase Reports
In one paragraph

Article in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert GalamagaCity of Hope, Goodyear, Arizona, USA.ORCID https://orcid.org/0009-0005-2088-3853
Stephanie JohnstonCity of Hope, Goodyear, Arizona, USA.
Cassaundra AcostaCity of Hope, Goodyear, Arizona, USA.

Funding

Sobi Inc.
6 · The paper itself

Abstract

Management of chemotherapy-induced thrombocytopenia (CIT) is challenging, often resulting in chemotherapy treatment delays, dose reduction, and treatment interruption. Randomized trials support the potential efficacy and safety of thrombopoietin receptor agonists in CIT management. A phase III trial of avatrombopag (AVA) demonstrated increased platelet counts (PC) in patients with solid tumours experiencing CIT. To complement those findings, this case series of six patients with solid tumours and CIT is presented. Results from these cases support the clinical benefit of AVA in improving PC and reducing the impact of CIT on tumour treatment, allowing continued therapy without dose reduction or treatment interruption.

Indexed as

Antineoplastic AgentsThiazolesThiophenesThrombocytopeniaAdultAgedFemaleHumansMaleMiddle AgedNeoplasmsPlatelet CountReceptors, ThrombopoietinTreatment OutcomeAntineoplastic AgentsavatrombopagReceptors, ThrombopoietinThiazolesThiophenesavatrombopagcase serieschemotherapy‐induced thrombocytopeniareal‐world datathrombopoietin receptor agonist

Identifiers

PMID39434457
PMCPMC11739760

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.