Evidence map›Paper›PMID 39434066›Full record

ArticleBMC psychiatry2024

A pre-post trial to examine biological mechanisms of the effects of time-restricted eating on symptoms and quality of life in bipolar disorder.

Sheri L Johnson, Greg Murray, Emily N C Manoogian, Liam Mason, J D Allen, Michael Berk, Satchidananda Panda, Nandini A Rajgopal, Jake C Gibson, Carter D Bower and 5 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06555406 (Time-restricted Eating as an Adjunctive Intervention for Bipolar Disorder), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06555406 narecruitingnot on this map

Time-restricted Eating as an Adjunctive Intervention for Bipolar Disorder

TypeinterventionalSponsorUniversity of California, BerkeleyRan2024 to 2029Enrolled150ConditionsBipolar Disorder, Time Restricted EatingArmsTime-restricted eating for 8 weeks
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sheri L JohnsonDepartment of Psychology, University of California, Berkeley, CA, USA.
Greg MurrayCentre for Mental Health, Swinburne University, Melbourne, VIC, 3122, Australia.
Emily N C ManoogianSalk Institute for Biological Studies, La Jolla, CA, USA.
Liam MasonResearch Department of Clinical, Educational and Health Psychology, University College London, London, UK.
J D AllenDepartment of Psychology, University of California, Berkeley, CA, USA.
Michael BerkIMPACT Institute, School of Medicine, Deakin University, Geelong, VIC, Australia.
Satchidananda PandaSalk Institute for Biological Studies, La Jolla, CA, USA.
Nandini A RajgopalDepartment of Psychology, University of California, Berkeley, CA, USA.
Jake C GibsonDepartment of Psychology, University of California, Berkeley, CA, USA.
Carter D BowerDepartment of Psychology, University of California, Berkeley, CA, USA.
Eline F BerleDepartment of Psychology, University of California, Berkeley, CA, USA.
Keanan JoynerDepartment of Psychology, University of California, Berkeley, CA, USA.
Robert VillanuevaDepartment of Psychology, University of California, Berkeley, CA, USA.
Erin E MichalakDepartment of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Lance J KriegsfeldDepartment of Psychology, University of California, Berkeley, CA, USA. Kriegsfeld@berkeley.edu.

Funding

Wellcome Trust 227087Wellcome Trust Grant number 227087/Z/23/Z
6 · The paper itself

Abstract

backgroundThe primary objective of this trial is to examine the mechanisms of time-restricted eating (TRE) as an adjunct to psychiatric care for people with bipolar disorder (BD) with sleep or circadian disruptions. This study builds on prior studies of circadian disruption in BD as well as growing evidence that TRE improves circadian functioning.

methodsOne-hundred fifty participants diagnosed with BD 1 or II will be recruited via advertising in the local community. Main inclusion criteria include: obtaining medical treatment for BD; current sleep or circadian problems; self-reported eating period of ≥ 12 h; no eating disorder or other health conditions that would hinder or limit the safety of following TRE; and not currently experiencing a mood episode, acute suicidality, psychosis, alcohol or substance use disorder. Participants will be asked to complete a baseline period in which daily food intake is logged online for two weeks. After baseline, participants will be asked to follow TRE for 8 weeks and to continue to complete daily food logging during this time. Symptom severity interviews will be conducted by phone or videoconference at baseline, mid-intervention (6 weeks post-baseline), end of intervention (10 weeks post-baseline), and 6 months post-baseline. Self-rated symptom severity and quality of life data will be gathered online at the same time points as symptom severity interviews, and at 16 weeks post-baseline (6 weeks after the TRE period ends). To assess potential mechanisms of change, we will examine the change in diurnal amplitude of 'clock' gene expression as a primary mediator at 8 weeks compared to baseline. We will further test whether diurnal amplitude of clock gene expression is predictive above and beyond the role of two covariate potential mediators, glucose tolerance and inflammation at 8 weeks relative to baseline. To provide an index of whether TRE successfully decreases emotional lability, participants will be asked to complete 5 mood assessments per day for 7 days at baseline and at 10 weeks. These mood assessments will be optional. DISCUSSION: The planned research will provide novel and important information on whether TRE improves sleep/circadian rhythm problems, along with reductions in mood symptoms and improvements in quality of life, for individuals with BD.

trial registrationClinicalTrials.gov ID: NCT06555406.

Indexed as

Bipolar DisorderQuality of LifeAdultClinical Trials as TopicFastingFemaleHumansMaleSleep Wake DisordersBipolar disorderCircadian rhythmsDepressionDiurnalInterventionManiaMetabolic healthQuality of lifeSleepTime-restricted eating

Identifiers

PMID39434066
PMCPMC11492775

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.