Evidence map›Paper›PMID 39434054›Full record

ArticleBMC microbiology2024

Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential.

Imran Shah, Zia Uddin, Maheer Hussain, Atif Ali Khan Khalil, Arshia Amin, Faisal Hanif, Liaqat Ali, Muhammad Imran Amirzada, Tawaf Ali Shah, Turki M Dawoud and 3 more

Abstract read
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In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Imran Shah *Department of Pharmacy, Comsats University Islamabad, Abbottabad Campus, Islamabad, Pakistan.
Zia Uddin *Department of Pharmacy, Comsats University Islamabad, Abbottabad Campus, Islamabad, Pakistan.
Maheer HussainDepartment of Biological Sciences, National University of Medical Sciences, Punjab, 46000, Pakistan.
Atif Ali Khan KhalilDepartment of Pharmacognosy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University, Lahore, Pakistan.
Arshia AminDepartment of Biosciences, Capital University of Science and Technology Islamabad, Islamabad, Pakistan.
Faisal HanifArmy Medical College, National University of Medical Sciences, Rawalpindi, 46000, Pakistan.
Liaqat AliDepartment of Biological Sciences, National University of Medical Sciences, Punjab, 46000, Pakistan.
Muhammad Imran AmirzadaDepartment of Pharmacy, Comsats University Islamabad, Abbottabad Campus, Islamabad, Pakistan.
Tawaf Ali ShahCollege of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.
Turki M DawoudDepartment of Botany and Microbiology, College of Science, King Saud University, P. O. BOX 2455, Riyadh, 11451, Saudi Arabia.
Mohammed BourhiaDepartment of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, IbnZohr University, Laayoune, 70000, Morocco.
Wen-Jun LiState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, 830011, China.
Wasim SajjadDepartment of Biological Sciences, National University of Medical Sciences, Punjab, 46000, Pakistan. sajjadw@numspak.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron homeostasis is vital for normal physiology, but in the majority of circumstances, like iron overload, this equilibrium is upset leading to free iron in the plasma. This condition with excess iron is known as hemochromatosis, which has been linked to many side effects, including cancer and liver cirrhosis. The current research aimed to investigate active molecules from Streptomyces sp. isolated from the extreme environment of Bahawalpur deserts. The strain was characterized using 16 S rRNA sequencing. Chemical analysis of the ethyl acetate cure extract revealed the presence of phenols, flavonoids, alkaloids, and tannins. Multiple ultraviolet (UV) active metabolites that were essential for the stated pharmacological activities were also demonstrated by thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Additionally, Gas chromatography/mass spectrometry (GC-MS) analysis revealed the primary constituents of the extract to compose of phenol and ester compounds. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to assess the extract's antioxidant capacity, and the results showed a good half-maximal inhibitory concentration (IC

Indexed as

AntioxidantsIron Chelating AgentsSoil MicrobiologyStreptomycesAlkaloidsCell SurvivalDesert ClimateFlavonoidsFree Radical ScavengersHumansIronPhenolsRNA, Ribosomal, 16STanninsAlkaloidsAntioxidantsFlavonoidsFree Radical ScavengersIronIron Chelating AgentsPhenolsRNA, Ribosomal, 16STanninsActinomycetesAntioxidantExtremophilesIron chealtionStreptomyces

Identifiers

PMID39434054
PMCPMC11492556

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.