Evidence map›Paper›PMID 39434009›Full record

SynthesisBMC cardiovascular disorders2024

Association of liver dysfunction with outcomes after percutaneous coronary intervention - a systematic review and meta-analysis.

Tulio Caldonazo, Hristo Kirov, Panagiotis Tasoudis, Marcus Franz, Markus Richter, Murat Mukharyamov, Alexander Zipprich, Ahmad Shana'ah, Diyar Haji, Torsten Doenst

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tulio Caldonazo *Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Hristo Kirov *Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Panagiotis TasoudisDivision of Cardiothoracic Surgery, University of North Carolina, Chapel Hill, USA.
Marcus FranzDivision of Cardiology, Department of Internal Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
Markus RichterDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Murat MukharyamovDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Alexander ZipprichDepartment of Internal Medicine IV (Gastroenterology, Hepatology, Infectiology), Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
Ahmad Shana'ahDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Diyar HajiDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany.
Torsten DoenstDepartment of Cardiothoracic Surgery, Jena University Hospital, Friedrich-Schiller-University, University of Jena, Am Klinikum 1, 07747, Jena, Germany. doenst@med.uni-jena.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver dysfunction is a known risk factor in the cardiovascular field. It specifically increases perioperative risk in patients undergoing coronary bypass surgery. Since percutaneous coronary intervention (PCI) is the much less invasive procedure for the treatment of coronary artery disease, we aimed to assess the relationship of liver dysfunction with outcomes in patients undergoing PCI.

methodsThree libraries were searched (MEDLINE, Web of Science and The Cochrane Library). We performed a meta-analysis of all studies in patients who underwent PCI that provided information on the presence or absence of liver dysfunction. Primary outcome was short-term mortality. Secondary outcomes were major adverse cardio- and cerebrovascular events (MACCE), bleeding and acute kidney injury. Random-effects model was applied.

resultsFive studies were selected and the data from 10,710,317 patients were included in the final analysis. In comparison with the absence of liver dysfunction, patients with liver dysfunction were associated with higher short-term mortality (OR 2.97, 95%CI 1.23-7.18, p = 0.02), higher MACCE (OR 1.42, 95%CI 1.08-1.87, p = 0.01), and higher bleeding (OR 2.23, 95%CI 1.65-3.00, p < 0.01). There was no significant difference regarding acute kidney injury (OR 1.20, 95%CI 0.50-2.87, p = 0.69).

conclusionsThe analysis suggests that liver dysfunction in patients undergoing PCI is independently associated with higher risk of short-term mortality and increased occurrence of MACCE and bleeding. However, there appears to be no association to acute kidney injury.

Indexed as

Coronary Artery DiseaseLiver DiseasesPercutaneous Coronary InterventionAcute Kidney InjuryHemorrhageHumansRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeCoronary artery diseaseLiver dysfunctionPercutaneous coronary intervention

Identifiers

PMID39434009
PMCPMC11492513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.