ArticleNature cardiovascular research2024
Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury.
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Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13citing papers in PubMed, 1 pooled it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- SIRT3 in post-myocardial infarction macrophage reprogramming: linking mitochondrial fitness to inflammation resolution and repair.Frontiers in immunology · 2026Pooled it
- The role of hypoxia-inducible factors in myocardial ischaemia-reperfusion injury and cardioprotection.Nature reviews. Cardiology · 2026Review
- Fate-mapping infiltrating monocytes following experimental myocardial infarction reveals differentiation trajectories in the infarcted heart.The Journal of clinical investigation · 2026Article
- Beyond β-Adrenergic Receptor Brake: Compartment-Selective GRK2 Programs from Heart Failure to Cardio-Oncology.Kinases and phosphatases · 2026Article
- DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function.Science immunology · 2026Article
- Macrophage polarization in ischemia-reperfusion injury: from molecular mechanisms to therapeutic strategies.Frontiers in immunology · 2026Review
- The immune-cardiovascular metabolic circuitry in myocardial ischemia-reperfusion injury: from metabolic signal release to spatiotemporal reprogramming.Frontiers in immunology · 2026Review
- Acute binge alcohol increases risk of arrhythmias and myocardial fibrosis in a mouse model of arrhythmogenic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025Article
- The Landscape of SPP1Immunology · 2025Review
- Macrophage induces angiogenesis via HIF signaling in denervated muscle following nerve injury.Scientific reports · 2025Article
- Functional diversity of cardiac macrophages in health and disease.Nature reviews. Cardiology · 2025Review
- The immune checkpoint regulator CD40 potentiates myocardial inflammation.Nature cardiovascular research · 2025Article
- Article
Corrections and comments
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Authors and funding
18 authors.
Farid F KadyrovCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Andrew L KoenigCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-4384-1267
Junedh M AmruteCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-6851-0168
Hao DunDivision of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Wenjun LiDivision of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Carla J WeinheimerCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Jessica M NigroCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Attila KovacsCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Andrea L BredemeyerCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-2970-5998
Steven YangCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Shibali DasCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Vinay R PennaCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Alekhya ParvathaneniCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Lulu LaiCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-3352-9467
Niklas HartmannCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0009-0009-1799-7162
Benjamin J KopeckyCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Daniel KreiselDivision of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA.
Kory J LavineCenter for Cardiovascular Research, Division of Cardiology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA. klavine@wustl.edu.ORCID http://orcid.org/0000-0003-1948-9945
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MNATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MThe Role of Donor Innate Immune Responses in Regulating Alloimmunity after Heart TransplantationR01HL151078 · NHLBI · WASHINGTON UNIVERSITY · PI KREISEL, DANIEL, LAVINE, KORY J. · 2020 to 2023
$2.6MMACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9MTraining in Integrative and Systems Biology of Cardiovascular DiseaseT32HL134635 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2017 to 2021
$1.8MMACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5MHIGH-RESOLUTON ULTRASOUND SYSTEM FOR PHENOTYPIC EVALUATION OF THE CARDIOVASCULAR SYSTEM IN MICES10OD028597 · OD · WASHINGTON UNIVERSITY · PI KOVACS, ATTILA · 2020 to 2020
$378kNCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL151078NHLBI NIH HHS R35 HL161185NHLBI NIH HHS T32 HL134635NIAMS NIH HHS P30 AR073752NIGMS NIH HHS T32 GM007067NIGMS NIH HHS T32 GM007200NIH HHS S10 OD028597
Abstract
Myocardial infarction initiates cardiac remodeling and is central to heart failure pathogenesis. Following myocardial ischemia-reperfusion injury, monocytes enter the heart and differentiate into diverse subpopulations of macrophages. Here we show that deletion of Hif1α, a hypoxia response transcription factor, in resident cardiac macrophages led to increased remodeling and overrepresentation of macrophages expressing arginase 1 (Arg1). Arg1
Indexed as
ArginaseCell DifferentiationHypoxia-Inducible Factor 1, alpha SubunitMacrophagesMonocytesMyocardial InfarctionAnimalsCell HypoxiaCell LineageDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial Reperfusion InjuryMyocardiumArg1 protein, mouseArginaseHif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunit
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.