Evidence map›Paper›PMID 39433816›Full record

ArticleScientific reports2024

Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells.

Maria Rosaria Ambrosio, Michiel Adriaens, Kasper Derks, Teresa Migliaccio, Valerio Costa, Domenico Liguoro, Simona Cataldi, Vittoria D'Esposito, Giovanni Maneli, Rita Bassolino and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maria Rosaria AmbrosioInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy. mariarosaria.ambrosio@cnr.it.
Michiel AdriaensMaastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
Kasper DerksDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
Teresa MigliaccioDepartment of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.
Valerio CostaInstitute of Genetics and Biophysics "A. Buzzati Traverso", National Council of Research (IGB-CNR), Naples, Italy.
Domenico LiguoroInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Simona CataldiInstitute of Genetics and Biophysics "A. Buzzati Traverso", National Council of Research (IGB-CNR), Naples, Italy.
Vittoria D'EspositoInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Giovanni ManeliDepartment of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.
Rita BassolinoDepartment of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.
Simone Di PaolaInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Marinella PirozziInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Fabrizio SchonauerDepartment of Public Health, University of Naples "Federico II", Naples, Italy.
Francesco D'AndreaDepartment of Public Health, University of Naples "Federico II", Naples, Italy.
Francesco BeguinotInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Ilja ArtsMaastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.
Pietro FormisanoInstitute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy. fpietro@unina.it.

Funding

Associazione Italiana per la Ricerca sul Cancro IG2023/29378European Foundation for the Study of Diabetes EFSD/Lilly Research Fellowship Programme 2016/0052351Ministero dell'Università e della Ricerca P2022LPJM4Ministero dell'Università e della Ricerca PRIN 2022 - n. 2022KTJLHLRegione Campania POR FESR 2014-2020 - COEPICA
6 · The paper itself

Abstract

An established hallmark of cancer cells is metabolic reprogramming, largely consisting in the exacerbated glucose uptake. Adipocytes in the tumor microenvironment contribute toward breast cancer (BC) progression and are highly responsive to metabolic fluctuations. Metabolic conditions characterizing obesity and/or diabetes associate with increased BC incidence and mortality. To explore BC-adipocytes interaction and define the impact of glucose in such dialogue, Mammary Adipose-derived Mesenchymal Stem Cells (MAd-MSCs) were differentiated into adipocytes and co-cultured with ER

Indexed as

AdipocytesBreast NeoplasmsCoculture TechniquesGlucoseCell DifferentiationCell Line, TumorCellular ReprogrammingFemaleHumansMesenchymal Stem CellsTranscriptomeTumor MicroenvironmentGlucoseAdipogenesisBreast CancerGlucoseMammary AdipocytesTranscriptional signaturesTumor Microenvironment

Identifiers

PMID39433816
PMCPMC11494089

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.