Evidence map›Paper›PMID 39433805›Full record

ArticleScientific reports2024

New insights in the mechanism of the SARS-CoV-2 M

Luca Sancineto, Francesca Mangiavacchi, Agnieszka Dabrowska, Agata J Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Cecilia Scimmi, Veronica Ceccucci, Juan Kong, Yao Zhao, Gianluca Ciancaleoni and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Selenium Nucleophilicity and Electrophilicity in the Intra- and Intermolecular SChemistry (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Luca SancinetoDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06100, PG, Italy.
Francesca MangiavacchiDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06100, PG, Italy.
Agnieszka DabrowskaVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, Krakow, 30-387, Poland.
Agata J Pacuła-MiszewskaDepartment of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland.
Magdalena Obieziurska-FabisiakDepartment of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland.
Cecilia ScimmiDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06100, PG, Italy.
Veronica CeccucciDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06100, PG, Italy.
Juan KongShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Yao ZhaoShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Gianluca CiancaleoniDipartimento di Chimica e Chimica Industriale (DCCI), Università di Pisa, Via Giuseppe Moruzzi, 13, Pisa, 56124, Italy.
Vanessa NascimentoDepartamento de Quımica Organica, Laboratorio de Sintese e Aplicaçao de Substancias Supramoleculares e Organocalcogenios (SupraSelen), Universidade Federal Fluminense, Outeiro Sao Joao Batista s/n, Niteroi, 24020-141, RJ, Brazil.
Bruno RizzutiDepartment of Physics, CNR-NANOTEC, SS Rende, University of Calabria, Rende, 87036, CS, Italy.
Marco BortoliDepartment of Chemistry and Hylleraas Centre for Quantum Molecular Sciences, University of Oslo, Oslo, 0315, Norway.
Laura OrianDipartimento di Scienze Chimiche, Università degli Studi di Padova, Padova, 35131, Italy.
Anna Kula-PacurarVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, Krakow, 30-387, Poland.
Haitao YangShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Jacek ŚcianowskiDepartment of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin Street, Torun, Poland.
Ying LeiShanghai Institute for Advanced Immunochemical Studies, School of Life Science and Technology, ShanghaiTech University, Shanghai, China. leiying@shanghaitech.edu.cn.
Krzysztof PyrcVirogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, Krakow, 30-387, Poland. k.a.pyrc@uj.edu.pl.
Claudio SantiDepartment of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia, 06100, PG, Italy. claudio.santi@unipg.it.

Funding

European UNion EU4Health Programme (EU4H)(https://health.ec.europa.eu/funding/eu4health-programme-2021-2027-vision-healthiereuropean-union_en#work-programmes) DURABLE projectMinistero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza 2018-2022Musecov: Multiscale Eco-evolution of Coronaviruses: from surveillance toward emergence prediction (https://www.era-learn.eu/network-information/networks/icrad/1st-icrad-call-2019/multiscale-eco-evolution-of-coronaviruses-from-surveillance-toward-emergence-prediction) ERAnet ICRAD-projectUniversity of Perugia Ricerca di Base
6 · The paper itself

Abstract

Although global vaccination campaigns alleviated the SARS-CoV-2 pandemic in terms of morbidity and mortality, the ability of the virus to originate mutants may reduce the efficacy of vaccines, posing a serious risk of a renewed pandemic. There is therefore a need to develop small molecules capable of targeting conserved viral targets, such as the main protease (M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesOrganoselenium CompoundsSARS-CoV-2COVID-19COVID-19 Drug TreatmentHumansMolecular Docking SimulationMolecular Dynamics SimulationProtease InhibitorsAntiviral AgentsCoronavirus 3C ProteasesOrganoselenium CompoundsProtease InhibitorsBenzisoselenazolonesDiselenidesEbselenGlutathioneSARS-CoV-2 main protease inhibitors

Identifiers

PMID39433805
PMCPMC11494035

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.