Evidence map›Paper›PMID 39433755›Full record

Observational studyScientific reports2024

Torque teno virus: a potential marker of immune reconstitution in youths with vertically acquired HIV.

Laura Tarancon-Diez, Itziar Carrasco, Laura Montes, Iker Falces-Romero, Elena Vazquez-Alejo, Santiago Jiménez de Ory, Marta Dapena, Jose Antonio Iribarren, Cristina Díez, Luis Ramos-Ruperto and 5 more

Abstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laura Tarancon-DiezServicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain. ltarancondiez@gmail.com.
Itziar CarrascoServicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Laura MontesGeneral Pediatrics and Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain.
Iker Falces-RomeroCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Elena Vazquez-AlejoMolecular Immunology Laboratoy, Hospital General Universitario Gregorio Marañón, Health Research Institute Gregorio Marañón (IiSGM), Madrid, Spain.
Santiago Jiménez de OryServicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Marta DapenaDepartment of Infectious Diseases, Hospital General de Castellón, Castellón, Spain.
Jose Antonio IribarrenHospital Universitario Donostia, IIS BioDonostia, San Sebastián, Spain.
Cristina DíezCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Luis Ramos-RupertoUniversity Hospital La Paz Research Institute (IdiPAZ), Madrid, Spain.
Elena ColinoHospital Materno Infantil Las Palmas, Las Palmas de Gran Canaria, Spain.
Cristina CalvoCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
Mª Ángeles Muñoz-FernandezMolecular Immunology Laboratoy, Hospital General Universitario Gregorio Marañón, Health Research Institute Gregorio Marañón (IiSGM), Madrid, Spain.
María Luisa NavarroServicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Talía SainzCentro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Funding

Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) CB22/01/00041Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII (CIBERINFEC) CB21/13/00025Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII (CIBERINFEC) CB21/13/00044Centro de Investigación Biomédica en Red de Enfermedades Infecciosas-ISCIII (CIBERINFEC) CB21/13/00077Instituto de Salud Carlos III (ISCIII). Miguel Servet Program CP23/00009
6 · The paper itself

Abstract

Torque teno virus (TTV) viral load (VL), a component of the human virome, increases during immune suppression or dysregulation. This study aimed to explore TTV VL in youths living with vertically acquired HIV (YWVH) and its potential as an immunovirological marker. We performed an observational, retrospective study involving YWVH under antiretroviral treatment (ART) from the Spanish Cohort of HIV-infected children, adolescents, and vertically HIV-infected patients transferred to Adult Units (CoRISpe-FARO), compared to HIV-negative healthy donors (HD). Plasma TTV VL was assessed by qPCR. T-cell phenotype was analysed on cryopreserved peripheral blood mononuclear cells by flow cytometry. Correlations with baseline CD4 and CD8 and long-term virological evolution were examined. A total of 57 YWVH were compared with 23 HD. YWVH had a median CD4 T-cells of 736 cells/mm

Indexed as

BiomarkersHIV InfectionsTorque teno virusViral LoadAdolescentAdultCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesChildFemaleHumansImmune ReconstitutionInfectious Disease Transmission, VerticalMaleRetrospective StudiesBiomarkersAntiretroviral treatmentCD4/CD8 ratioImmune reconstitutionTTVYouths with vertically acquired HIV

Identifiers

PMID39433755
PMCPMC11494008

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.