Continuous Wireless Telemetric Measurement of Intraocular Pressure (IOP), Ocular Perfusion Pressure (OPP), and Cerebrospinal Fluid Pressure (CSFP) in Nonhuman Primates (NHPs).

J Crawford Downs

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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1 citing paper in PubMed.

Considerations and implications of currentFrontiers in cell and developmental biology · 2025
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5 · Who and what money

Authors and funding

1 author.

J Crawford DownsDepartment of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. cdowns@uabmc.edu.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026

$16.9M

IOP and OPP Fluctuation as Risk Factors for GlaucomaR01EY026035 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI J CRAWFORD DOWNS · 2016 to 2026

$5.2M

Shared Instrumentation for Pre- Post- and Intra-operative Ocular ImagingS10OD026752 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAMLIN, PAUL DOUGLAS · 2019 to 2019

$548k

NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY026035NIH HHS S10 OD026752

6 · The paper itself

Abstract

Intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) telemetry in large animal models can be used to determine the exact IOP, CSFP, translaminar pressure, and translaminar pressure gradient exposure that each normal and treated eye is subjected to relative to its fellow eye. In this way, it is possible to determine the independent contributions of each of these parameters (mean and/or transient fluctuations) to the risk of both the onset and rate of progression of glaucoma. Importantly, we have shown that IOP and CSFP fluctuate continuously by up to 100% over the course of the day, so snapshot cage-side IOP measurements are unable to adequately capture the pressure in the eye; CSFP is not measurable noninvasively at all. Implementation of IOP and CSFP telemetry will allow us to precisely determine the pressure insult in each eye of each animal and thereby unravel the true mechanisms underlying pressure-induced damage to the retinal ganglion cells in glaucoma.

Indexed as

Cerebrospinal Fluid PressureIntraocular PressureTelemetryAnimalsDisease Models, AnimalGlaucomaPrimatesTonometry, OcularWireless TechnologyIntraocular pressure fluctuationsLamina cribrosaLong-term IOP monitoringMechanical stress

Identifiers

PMID39433682

DOI10.1007/978-1-0716-4140-8_21

PMCPMC12002344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.