Evidence map›Paper›PMID 39433673›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Mouse Model of Glucocorticoid-Induced Glaucoma.

Prabhavathi Maddineni, Yogapriya Sundaresan, Gulab Zode

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Prabhavathi MaddineniGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA.
Yogapriya SundaresanGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA.
Gulab ZodeGavin Herbert Eye Institute-Center for Translational Vision Research, Department of Ophthalmology, Department of Physiology and Biophysics, University of California Irvine School of Medicine, Irvine, California, USA. gzode@uci.edu.

Funding

Targeting ER Stress Pathway Using Sodium 4-Phenylbutyrate for the Treatment of POAGR01EY028616 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ZODE, GULAB · 2018 to 2021
$1.4M
The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegenerationR00EY032982 · NEI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Prabhavathi Maddineni · 2024 to 2026
$758k
Development and characterization of an inducible model for myocilin POAGR21EY034333 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZODE, GULAB · 2023 to 2024
$432k
The role of impaired mitophagy and mitochondrial dysfunction in glaucomatous neurodegenerationK99EY032982 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI MADDINENI, PRABHAVATHI · 2021 to 2022
$199k
NEI NIH HHS K99 EY032982NEI NIH HHS R00 EY032982NEI NIH HHS R01 EY028616NEI NIH HHS R21 EY034333
6 · The paper itself

Abstract

Extended glucocorticoid (GC) treatment can lead to ocular hypertension and induce iatrogenic open-angle glaucoma. GC-induced glaucoma mimics many clinical and pathological features of primary open-angle glaucoma (POAG), and therefore mouse models of GC-induced glaucoma are utilized to study pathophysiology of glaucoma. We have recently demonstrated that weekly periocular injections of dexamethasone-21-acetate (Dex-Ac) lead to robust and significant intraocular pressure (IOP) elevation, retinal ganglion cell (RGC) loss, and optic nerve degeneration in mice. Our mouse model exhibits signature features of POAG including significant IOP elevation due to reduced outflow facility, progressive optic nerve degeneration, and structural and functional loss of RGCs. Dex-induced IOP elevation is associated with increased aqueous outflow resistance due to trabecular meshwork (TM) dysfunction including excessive extracellular matrix deposition and induction of endoplasmic reticulum stress. Mouse model of Dex-induced glaucoma represents an ideal animal model to investigate both glaucomatous damage to the TM and RGC axons and to develop novel therapies. Here, we present a detailed protocol for developing this model in laboratory settings.

Indexed as

DexamethasoneDisease Models, AnimalGlucocorticoidsIntraocular PressureTrabecular MeshworkAnimalsGlaucomaGlaucoma, Open-AngleMiceRetinal Ganglion CellsDexamethasoneGlucocorticoidsGlucocorticoidsMouse model of glaucomaNeurodegenerationOcular hypertensionOutflow facilityPattern electroretinogramTrabecular meshwork

Identifiers

PMID39433673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.