ArticleMethods in molecular biology (Clifton, N.J.)2025
Segmental Aqueous Humor Outflow.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Of the known risk factors for glaucoma, elevated intraocular pressure (IOP), is the primary one. The conventional aqueous humor outflow pathway contains the key source of IOP regulation, which is predominantly the trabecular meshwork (TM). Studies of outflow have demonstrated that the outflow pathway is not uniform around the circumference of the eye but highly segmental with regions of relative high flow (HF) and intermediate or medium flow (IF) and regions of low or no flow (LF). Herein we present protocols that we use to study outflow segmentation through the conventional outflow pathway, mostly focusing on human eyes. These methods are quite similar for nonhuman primates and other species. These studies are mostly conducted using ex vivo intact globes or perfused anterior segment organ culture. One potential therapy for IOP reduction in those with elevated IOP to reduce progression of glaucomatous optic nerve damage would be to increase HF or IF and reduce LF proportions.
Indexed as
Identifiers
39433670What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.