Evidence map›Paper›PMID 39433665›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Measurements of Phagocytosis in Trabecular Meshwork Cells.

Jennifer A Faralli, Mark S Filla, Caleigh Dunn, Donna M Peters

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jennifer A FaralliDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mark S FillaDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Caleigh DunnDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Donna M PetersDepartment of Pathology & Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. dmpeter2@wisc.edu.

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI Donna M Peters · 2005 to 2026
$12.6M
Control of Trabecular Meshwork CytoskeletonR01EY017006 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, DONNA M · 2006 to 2024
$6.1M
NFAT and fibrosis in the trabecular meshworkR01EY032905 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, DONNA M · 2022 to 2025
$1.7M
Control of ECM HomeostasisR01EY026009 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, DONNA M · 2016 to 2019
$1.4M
NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY017006NEI NIH HHS R01 EY026009NEI NIH HHS R01 EY032905
6 · The paper itself

Abstract

The restriction in the movement of aqueous humor through the trabecular meshwork is known to play an important role in the pathogenesis of glaucomas. Among the functions of the trabecular meshwork that help to prevent this restriction and maintain the movement of aqueous humor is phagocytosis. Cells in the trabecular meshwork actively phagocytose pigment, cellular debris, and other materials in order to help keep the drainage pathway clear. A decrease in phagocytosis has thus been implicated in the development of glaucomas. In this chapter, we outline two methods using fluorescent markers that can be used to measure the phagocytic properties of trabecular meshwork cells in culture.

Indexed as

PhagocytosisTrabecular MeshworkAnimalsCells, CulturedFluorescent DyesHumansFluorescent DyesCell culturesGlaucomaImmunofluorescence microscopyPhagocytosisTrabecular meshwork

Identifiers

PMID39433665

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.