Evidence map›Paper›PMID 39433621›Full record

ArticleScientific reports2024

Dendrite injury triggers neuroprotection in Drosophila models of neurodegenerative disease.

Sydney E Prange, Isha N Bhakta, Daria Sysoeva, Grace E Jean, Anjali Madisetti, Hieu H N Le, Ly U Duong, Patrick T Hwu, Jaela G Melton, Katherine L Thompson-Peer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sydney E PrangeDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Isha N BhaktaDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Daria SysoevaDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Grace E JeanDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Anjali MadisettiDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Hieu H N LeDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Ly U DuongDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Patrick T HwuDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Jaela G MeltonCenter for the Neurobiology of Learning and Memory, Irvine, CA, USA.
Katherine L Thompson-PeerDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA. ktpeer@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Mechanisms of Dendrite Regeneration after InjuryR00NS097627 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI THOMPSON-PEER, KATHERINE LOUISE · 2019 to 2021
$744k
Zeiss LSM 980 NLO Confocal Microscope with Airyscan2 for UCI Optical Biology CoreS10OD032327 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WARRIOR, RAHUL · 2022 to 2022
$600k
NCI NIH HHS P30 CA062203NIGMS NIH HHS P50 GM076516NIH HHS S10 OD032327NINDS NIH HHS R00 NS097627
6 · The paper itself

Abstract

Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis. Dendrite degeneration can be modeled by expressing pathogenic polyglutamine disease transgenes in Drosophila neurons in vivo. Here, we show that we can protect against dendrite loss in neurons modeling neurodegenerative polyglutamine diseases through injury to a single primary dendrite branch. We find that this neuroprotection is specific to injury-induced activation of dendrite regeneration: neither injury to the axon nor injury just to surrounding tissues induces this response. We show that the mechanism of this regenerative response is stabilization of the actin (but not microtubule) cytoskeleton. We also demonstrate that this regenerative response may extend to other neurodegenerative diseases. Together, we provide evidence that activating dendrite regeneration pathways has the potential to slow-or even reverse-dendrite loss in neurodegenerative disease.

Indexed as

DendritesDisease Models, AnimalNeurodegenerative DiseasesNeuroprotectionAnimalsDrosophilaDrosophila melanogasterNeuronsPeptidesPeptidespolyglutamineAxon injuryDendrite injuryDrosophilaNeurodegenerative diseaseNeuroprotectionRegeneration

Identifiers

PMID39433621
PMCPMC11494097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.