Evidence map›Paper›PMID 39433608›Full record

ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2025

[Severe intoxication after yew (Taxus) ingestion-case report and literature review].

J L Lohmeyer, C Enneking, P Mammen, T Horlacher, M Roiss, G N Schmidt, M W Bergmann, T Spangenberg

Abstract readCase ReportsReviewEnglish Abstract
PubMed Publisher
In one paragraph

Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Successful Organ Donation After Yew Intoxication.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J L LohmeyerAbteilung für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland. j.lohmeyer@asklepios.com.ORCID http://orcid.org/0009-0008-4732-1924
C EnnekingAbteilung für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
P MammenAsklepios Klinik Altona, Abteilung für Kardiologie und internistische Intensivmedizin, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
T HorlacherAbteilung für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
M RoissAbteilung für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
G N SchmidtAbteilung für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
M W BergmannAsklepios Klinik Altona, Abteilung für Kardiologie und internistische Intensivmedizin, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.
T SpangenbergAsklepios Klinik Altona, Abteilung für Kardiologie und internistische Intensivmedizin, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere yew (Taxus) intoxication is a rare condition that can lead to life-threatening cardiac arrhythmia. The survival of patients requires highly specialized emergency and intensive care treatment.

objectivesSystematic overview of the clinical picture and important treatment options.

methodsCase report of severe yew intoxication with subsequent literature review of comparable case reports. Analysis of 33 case reports with a total of 37 critically intoxicated patients from the years 2000-2024 from Europe and North America.

resultsSevere yew intoxications were almost exclusively the result of suicidal intent. Patients average age was 33 (± 14.5) years. The use of antiarrhythmic drugs and electrical stimulation of the heart often proved to be ineffective or deteriorating in its effect over time. The use of lipid emulsion and/or digoxin-specific Fab fragments has little evidence. The average duration of a clinically relevant arrhythmogenic effect was 22±11.7 h.

conclusionsThe management of yew intoxication is primarily limited to symptomatic treatment. The availability of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in a "bridge-to-recovery" concept appears to be of utmost importance.

Indexed as

Arrhythmias, CardiacSuicide, AttemptedTaxusAdultCritical CareExtracorporeal Membrane OxygenationFemaleHumansMaleMiddle AgedDigoxin-specific Fab fragmentsExtracorporeal life supportLipid emulsionTaxin alkaloidsTaxus baccata

Identifiers

PMID39433608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.