Evidence map›Paper›PMID 39433576›Full record

ArticleMikrochimica acta2024

Synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral metal-organic framework and chiral molecularly imprinted polymer in capillary electrochromatography.

Pandeng Miao, Dongyang Zhu, Shuaijing Du, Yingxiang Du

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pandeng Miao *Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, Jiangsu, 210009, P. R. China.
Dongyang Zhu *Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, Jiangsu, 210009, P. R. China.
Shuaijing DuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. shuaijingdu@ucla.edu.
Yingxiang DuKey Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, Jiangsu, 210009, P. R. China. du_yingxiang@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A capillary electrochromatography (CEC) synergistic enantioseparation system based on a novel nanomaterial synthesized by chiral molecularly imprinted polymers (CMIPs) and chiral metal organic frameworks (CMOFs) was developed. Compared with CMIPs and CMOFs alone, the enantioseparation performance of ofloxacin (OFL) of the CEC with the novel nanomaterial as stationary phases was greatly improved. CMOFs with chiral recognition ability have synergize with CMIPs to greatly improve the chiral selectivity of the novel stationary phases in CEC. As a proof-of-concept demonstration, a coated capillary column was prepared by a sol-gel method using S-OFL (template), iron-based cyclodextrin MOF (Fe-CD-MOF, a CMOF), 3-aminopropyltriethoxysilane (functional monomer), and tetraethyl orthosilicate (cross-linking agent). Then, the newly constructed CEC system has excellent enantioseparation performance of OFL with a resolution of 3.92. Finally, computerized molecular docking revealed that the difference in the binding ability of Fe-CD-MOF to ofloxacin enantiomers was an important mechanism for CEC chiral separation. This innovative development of synergistic chiral stationary phases based on CMOFs and CMIPs creates a highly efficient potential direction for enantiomer separation.

Indexed as

Capillary electrochromatographyChiral metal organic frameworksChiral molecularly imprinted polymersEnantioseparationOfloxacin

Identifiers

PMID39433576

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.