Evidence map›Paper›PMID 39433445›Full record

ArticleBJU international2025

Comparative effectiveness of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy for bladder cancer.

Pierre-Etienne Gabriel, Ugo Pinar, Louis Lenfant, Jérôme Parra, Christophe Vaessen, Pierre Mozer, Emmanuel Chartier-Kastler, Morgan Rouprêt, Thomas Seisen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BJU international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pierre-Etienne GabrielGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.ORCID https://orcid.org/0009-0000-5263-1398
Ugo PinarGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Louis LenfantGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Jérôme ParraGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Christophe VaessenGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Pierre MozerGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Emmanuel Chartier-KastlerGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Morgan RouprêtGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.
Thomas SeisenGRC 5, Predictive Onco-Urology, APHP, Pitié-Salpêtrière Hôpital, Urology, Sorbonne University, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the comparative effectiveness of robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) vs open radical cystectomy (ORC) for bladder cancer (BC). PATIENTS AND

methodsWe conducted a real-life monocentric study including all consecutive patients who underwent RARC with ICUD or ORC for BC at our institution from 2014 to 2023. Uni- and multivariable logistic and Cox regression analyses were used to compare perioperative, oncological and stricture outcomes between both groups by calculating odds (ORs) and hazard (HRs) ratios with their corresponding 95% confidence intervals (CIs), respectively.

resultsOverall, 316 patients underwent either RARC with ICUD (n = 228 [72.2%]) or ORC (n = 88 [27.8%]). The perioperative benefits of RARC vs ORC included decreased risks of major blood loss (OR 0.10, 95% CI 0.04-0.23; P < 0.001), perioperative transfusion (OR 0.30, 95% CI 0.16-0.57; P < 0.001), 90-day major complications (OR 0.56, 95% CI 0.29-0.99; P = 0.04), and prolonged initial length of hospital stay (OR 0.20, 95% CI 0.09-0.35; P < 0.001), as well as more days alive and out of the hospital within 90 days of surgery (OR 2.56, 95% CI 1.46-4.6; P < 0.01). In addition, the use of RARC vs ORC was associated with a higher lymph node (LN) count (OR 3.35, 95% CI 1.83-6.30; P < 0.001), while there was no significant difference in recurrence-free (HR 0.72, 95% CI 0.49-1.07; P = 0.1), cancer-specific (HR 0.69, 95% CI 0.43-1.10; P = 0.1), overall (HR 0.76, 95% CI 0.47-1.20; P = 0.3) and uretero-ileal stricture-free (HR 1.18, 95% CI 0.62-2.25; P = 0.6) survival between both groups after a median (interquartile range) follow-up of 42.3 (16.4-73.8) months.

conclusionOur real-world study supports the effectiveness of RARC with ICUD vs ORC for BC. We generally observed better perioperative outcomes, as well as similar oncological-except for higher LN count-and uretero-ileal stricture outcomes after RARC with ICUD vs ORC.

Indexed as

CystectomyRobotic Surgical ProceduresUrinary Bladder NeoplasmsUrinary DiversionAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment Outcomebladder cancercomparative effectiveness researchpostoperative complicationsradical cystectomyrobotic surgical procedures

Identifiers

PMID39433445
PMCPMC11842888

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.