Evidence map›Paper›PMID 39432749›Full record

ArticleACS infectious diseases2024

Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[

Alyssa C Pollard-Kerning, Kaixuan Li, Yong Li, Shin Hye Ahn, Mingqian Wang, Melike Akoglu, Eduardo Bravo, Francesca DelloRusso, Hari K Akula, Wenchao Qu and 4 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Highlights on U.S. FDA-approved halogen-containing drugs in 2024.European journal of medicinal chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alyssa C Pollard-KerningCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Kaixuan LiCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Yong LiCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Shin Hye AhnCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0003-4700-4861
Mingqian WangCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Melike AkogluCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Eduardo BravoCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Francesca DelloRussoCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.
Hari K AkulaDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York 11794-8101, United States.
Wenchao QuDepartment of Psychiatry and Behavioral Health, Renaissance School of Medicine at Stony Brook University, Stony Brook, New York 11794-8101, United States.ORCID 0000-0003-3107-7281
Labros MeimetisChronus Pharmaceuticals Inc., Long Island High Technology Incubator, 25 Health Sciences Drive, Stony Brook, New York 11790-3350, United States.
David J SchlyerIsotope Research and Production, Brookhaven National Lab, Upton, New York 11973-5000, United States.
David E KomatsuDepartment of Orthopedics, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York 11794-8181, United States.
Peter J TongeCenter for Advanced Study of Drug Action and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States.ORCID 0000-0003-1606-3471

Funding

Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
Novel PET Radiotracers for Imaging InfectionR01EB024549 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI TONGE, PETER J · 2018 to 2021
$1.4M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM127253 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TSIRKA, STYLIANI-ANNA (STELLA) E · 2018 to 2022
$689k
Evaluation of a Novel Infection PET DiagnosticR41EB027050 · NIBIB · CHRONUS PHARMACEUTICALS, INC. · PI TONGE, PETER J · 2018 to 2019
$229k
A PET Diagnostic for Imaging Bacterial InfectionR41EB029860 · NIBIB · CHRONUS PHARMACEUTICALS, INC. · PI TONGE, PETER J · 2020 to 2020
$221k
NIBIB NIH HHS R01 EB024549NIBIB NIH HHS R41 EB027050NIBIB NIH HHS R41 EB029860NIGMS NIH HHS T32 GM127253NIGMS NIH HHS T32 GM136572
6 · The paper itself

Abstract

Deep-seated bacterial infections are difficult to detect and diagnose due to the lack of specific clinical imaging modalities. Therefore, the bacteria-specific positron emission tomography radiotracer 2-[

Indexed as

Positron-Emission TomographyProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcus aureus4-Aminobenzoic AcidAnimalsDisease Models, AnimalFemaleFluorine RadioisotopesMiceRadiopharmaceuticals4-Aminobenzoic AcidFluorine RadioisotopesRadiopharmaceuticalsbacterial infection imagingdosimetryfluorine-18positron emission tomographyprosthetic joint infectionradiotracer

Identifiers

PMID39432749
PMCPMC12117573

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.