Evidence map›Paper›PMID 39432581›Full record

ArticleThe Journal of infectious diseases2025

Pathological Insights into Lassa Virus-Induced Vestibular Dysfunction in Mice: Histopathological Analysis of the Inner Ear Vestibular Apparatus.

Tomoharu Suzuki, Marina Hosotani Saito, Nantian Lin, Atsushi Tamura, Nadezhda Yun, Takaaki Koma, Junki Maruyama, Slobodan Paessler, Tomoko Makishima

Abstract read
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In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tomoharu SuzukiDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0009-0008-4862-1881
Marina Hosotani SaitoDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-0360-3360
Nantian LinDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
Atsushi TamuraDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.
Nadezhda YunDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0009-0007-8217-0247
Takaaki KomaDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Junki MaruyamaDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-0088-4793
Slobodan PaesslerDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Tomoko MakishimaDepartment of Otolaryngology, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0003-3397-6395

Funding

West African Center for Emerging Infectious DiseasesU01AI151801 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Robert W Cross, Scott C Weaver · 2020 to 2026
$10.1M
Sequelae of Lassa FeverR01AI129198 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PAESSLER, SLOBODAN · 2018 to 2022
$3.9M
Balance Dysfunction Induced by Lassa Virus InfectionR01DC021542 · NIDCD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Tomoko Makishima · 2024 to 2026
$1.9M
Viral factors responsible for Lassa virus pathogenicityR00AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2023 to 2024
$498k
Viral factors responsible for Lassa virus pathogenicityK99AI156012 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MARUYAMA, JUNKI · 2021 to 2022
$177k
Astellas Foundationfor Research on Metabolic DisordersJapan Society for the Promotion of ScienceJohn S. Dunn EndowmentNational Institute of Allergy and Infectious Diseases U01AI151801NIAID NIH HHS K99 AI156012NIAID NIH HHS R00 AI156012NIAID NIH HHS R01 AI129198NIAID NIH HHS U01 AI151801NIDCD NIH HHS R01 DC021542NIH HHS R01 AI129198Uehara Memorial FoundationUniversity of Texas Medical Branch
6 · The paper itself

Abstract

Lassa fever (LF), caused by Lassa virus (LASV) infection, typically leads to mild symptoms in humans, but some survivors experience audiovestibular problems. Here we present vestibular histopathological insights in our LF model mice. We observed (1) hemorrhage within the vestibular ganglion and stroma beneath the sensory epithelium, (2) preserved hair cells and supporting cells, (3) LASV antigen presence in the vestibular ganglion cells and the stroma beneath the sensory epithelium, and (4) CD3-positive T-lymphocyte infiltration in the vestibular ganglion and the stroma underlying the sensory epithelium. LASV and/or its immune response likely contributes to the pathogenesis of vestibular dysfunction.

Indexed as

Lassa FeverLassa virusVestibular DiseasesVestibule, LabyrinthAnimalsDisease Models, AnimalMiceT-Lymphocytesinner earLassa feverLassa viruspathologyvestibular apparatus

Identifiers

PMID39432581
PMCPMC11998552

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.