Evidence map›Paper›PMID 39432092›Full record

ArticleVirchows Archiv : an international journal of pathology2025

Cyclin-D1 rearrangement as a secondary event in the large cell transformation of splenic marginal zone lymphoma with a TP53 deletion.

Giby V George, Diana G Adlowitz, K Riley Okeson, Fatima Zahra Jelloul, Hong Fang, Wei Wang, Dennis P O'Malley, L Jeffrey Medeiros, Siba El Hussein

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Giby V GeorgeDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Diana G AdlowitzDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
K Riley OkesonDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Fatima Zahra JelloulDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hong FangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wei WangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Dennis P O'MalleyNeoGenomics, Aliso Viejo, CA, USA.
L Jeffrey MedeirosDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Siba El HusseinDepartment of Pathology, University of Vermont Larner College of Medicine, Burlington, VT, USA. elhusseinsiba@gmail.com.ORCID http://orcid.org/0000-0002-1338-7107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

igh:CCND1 translocation has been implicated as a preliminary finding in mantle cell lymphoma (MCL) and plasma cell myeloma, with cyclin D1 over-expression by immunohistochemistry stain, without gene rearrangement, reported in other hematologic neoplasms. CCND1 rearrangement has been reported infrequently as a secondary event in high-grade B-cell lymphomas. We present the case of an elderly man who was found to have a splenic marginal zone lymphoma with a heterozygous TP53 deletion. Years later at the time of relapse, the patient acquired a CCND1 rearrangement, in addition to a persistent TP53 deletion. Sequencing of the two lymphomas demonstrated clonal relatedness of the two processes. To our knowledge, this is the first report of a splenic marginal zone lymphoma with a TP53 deletion at diagnosis, evolving into a large B-cell lymphoma with a CCND1 rearrangement.

Indexed as

Cell Transformation, NeoplasticCyclin D1Gene RearrangementLymphoma, B-Cell, Marginal ZoneLymphoma, Large B-Cell, DiffuseSplenic NeoplasmsTumor Suppressor Protein p53AgedGene DeletionHumansMaleCCND1 protein, humanCyclin D1TP53 protein, humanTumor Suppressor Protein p53Cyclin-D1 rearrangementHigh grade B-cell lymphomaMantle cell lymphomaSecondary eventSplenic marginal zone lymphomaTP53 deletion

Identifiers

PMID39432092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.