Evidence map›Paper›PMID 39432069›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Pyrazolyl amide-chalcones conjugates: Synthesis and antikinetoplastid activity.

Devesh S Agarwal, Richard M Beteck, Dorien Mabille, Guy Caljon, Lesetja J Legoabe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Devesh S AgarwalCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Richard M BeteckCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Dorien MabilleLaboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Lesetja J LegoabeCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa. lesetja.legoabe@nwu.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel pyrazolyl amide-chalcones conjugates was synthesized in five steps and evaluated against a range of medically important kinetoplastid parasites including Trypanosoma cruzi, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Leishmania infantum. In addition, the series was also tested for in vitro cytotoxicity activity against human lung fibroblasts and primary mouse macrophages. Among all synthetised compounds, 9b was found to be the most active against T. b. brucei with an IC

Indexed as

AmidesAntiprotozoal AgentsChalconesPyrazolesAnimalsFibroblastsHumansLeishmania infantumMacrophagesMiceStructure-Activity RelationshipTrypanosoma brucei bruceiAmidesAntiprotozoal AgentsChalconesPyrazolesAmidesAntikinetoplastidChalconesDrug likeliness propertiesPyrazoles

Identifiers

PMID39432069
PMCPMC11978679

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.