Evidence map›Paper›PMID 39431848›Full record

ArticleJournal of virology2024

A measles virus collective infectious unit that caused lethal human brain disease includes many locally restricted and few widespread copy-back defective genomes.

Biruhalem Taye, Iris Yousaf, Chanakha K Navaratnarajah, Declan C Schroeder, Christian K Pfaller, Roberto Cattaneo

Abstract read
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Biruhalem TayeDepartment of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6866-022X
Iris YousafDepartment of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Chanakha K NavaratnarajahDepartment of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Declan C SchroederDepartment of Veterinary Population Medicine, University of Minnesota, St. Paul, Minnesota, USA.ORCID 0000-0001-5991-2838
Christian K PfallerDepartment of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-3302-0780
Roberto CattaneoDepartment of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6881-2548

Funding

Intercellular transfer of cytoplasm and measles virus through nectinsR01AI143791 · NIAID · MAYO CLINIC ROCHESTER · PI CATTANEO, ROBERTO B. · 2020 to 2023
$2.0M
Lethal human brain infection by measles virus: phylogeography and mechanismsR21AI159230 · NIAID · MAYO CLINIC ROCHESTER · PI CATTANEO, ROBERTO B. · 2021 to 2022
$451k
NIAID NIH HHS R01 AI143791NIAID NIH HHS R21 AI159230
6 · The paper itself

Abstract

During virus replication in cultured cells, copy-back defective viral genomes (cbDVGs) can arise. CbDVGs are powerful inducers of innate immune responses

Indexed as

BrainGenome, ViralMeaslesMeasles virusSubacute Sclerosing PanencephalitisVirus ReplicationHumansImmunity, Innatebrain transcriptomebrain tropismcollective infectious unitcopy-back defective viral genomedefective interferingdefective viral genomeshuman braininnate immune responsemeasles virussubacute sclerosing panencephalitis

Identifiers

PMID39431848
PMCPMC11575405

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.