Evidence map›Paper›PMID 39431827›Full record

ArticlemBio2024

Rab6a enables BICD2/dynein-mediated trafficking of human papillomavirus from the

Jeongjoon Choi, Kaitlyn Speckhart, Billy Tsai, Daniel DiMaio

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeongjoon ChoiDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.
Kaitlyn SpeckhartDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Billy TsaiDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0003-2859-1415
Daniel DiMaioDepartment of Genetics, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-2060-5977

Funding

Mechanisms of human papillomavirus entryR35CA242462 · NCI · YALE UNIVERSITY · PI Daniel C. Dimaio · 2020 to 2026
$6.9M
Cellular and Molecular Biology at MichiganT32GM145470 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI John Chadwick Brenner · 2022 to 2026
$4.1M
Retrograde TGN/Golgi transport and nuclear targeting of HPV during entryR01AI150897 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Daniel C. Dimaio, Billy Tsai · 2020 to 2026
$3.5M
Elucidating the role of dynein-cargo adaptor proteins in Human papillomavirus infectionF31AI169887 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPECKHART, KAITLYN NOEL · 2022 to 2024
$124k
HHS | National Institutes of Health (NIH) AI150897HHS | National Institutes of Health (NIH) CA242462HHS National Institutes of Health (NIH) AI169887NCI NIH HHS R35 CA242462NIAID NIH HHS F31 AI169887NIAID NIH HHS R01 AI150897NIGMS NIH HHS T32 GM145470
6 · The paper itself

Abstract

Rab GTPases control intracellular vesicular transport, including retrograde trafficking of human papillomavirus (HPV) during cell entry, guiding the virus from the endosome to the IMPORTANCE: Human papillomaviruses (HPVs) are small, non-enveloped DNA viruses that cause approximately 5% of human cancer. Like most other DNA viruses, HPV traffics to the nucleus during virus entry to successfully infect cells. We show here that HPV utilizes a cellular enzyme, Rab6a, during virus entry to engage the dynein molecular motor for transport along microtubules. Rab6a is required for complex formation between the HPV L2 capsid protein, dynein, and the dynein adaptor BICD2 in the

Indexed as

Dyneinsrab GTP-Binding Proteinstrans-Golgi NetworkVirus InternalizationCapsid ProteinsHeLa CellsHuman papillomavirus 16Human Papillomavirus VirusesHumansMicrotubule-Associated ProteinsOncogene Proteins, ViralPapillomavirus InfectionsProtein TransportBICD2 protein, humanCapsid ProteinsDyneinsMicrotubule-Associated ProteinsOncogene Proteins, ViralRab6 proteinrab GTP-Binding ProteinsBICD2dyneinHPVL2 proteinRab33bRab6aretrograde transporttrans-Golgi networkvirus trafficking

Identifiers

PMID39431827
PMCPMC11559006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.