Evidence map›Paper›PMID 39431552›Full record

ReviewJournal of cellular and molecular medicine2024

Unveiling exosomes: Cutting-edge isolation techniques and their therapeutic potential.

Farnaz Sani, Faezeh Shafiei, Farshad Dehghani, Yasaman Mohammadi, Mohammadhossein Khorraminejad-Shirazi, Abbas Fazel Anvari-Yazdi, Zahra Moayedfard, Negar Azarpira, Mahsa Sani

Abstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Exosomes as a biomarker in postoperative complications: a literature review.Frontiers in cell and developmental biology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Isolation methods of exosomes derived from dental stem cells.International journal of oral science · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Emerging Biomimetic Drug Delivery Nanoparticles Inspired by Extracellular Vesicles.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Farnaz SaniShiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Faezeh ShafieiShiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Farshad DehghaniShiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Yasaman MohammadiPharmaceutical Sciences Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Mohammadhossein Khorraminejad-ShiraziDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abbas Fazel Anvari-YazdiDivision of Biomedical Engineering, University of Saskatchewan, Saskatoon, Canada.
Zahra MoayedfardDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Negar AzarpiraShiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-5549-0057
Mahsa SaniShiraz Institute for Stem Cell & Regenerative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID 0000-0002-0379-6572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are one type of nanosized membrane vesicles with an endocytic origin. They are secreted by almost all cell types and play diverse functional roles. It is essential for research purposes to differentiate exosomes from microvesicles and isolate them from other components in a fluid sample or cell culture medium. Exosomes are important mediators in cell-cell communication. They deliver their cargos, such as mRNA transcripts, microRNA, lipids, cytosolic and membrane proteins and enzymes, to target cells with or without physical connections between cells. They are highly heterogeneous in size, and their biological functions can vary depending on the cell type, their ability to interact with recipient cells and transport their contents, and the environment in which they are produced. This review summarized the recent progress in exosome isolation and characterization techniques. Moreover, we review the therapeutic approaches, biological functions of exosomes in disease progression, tumour metastasis regulation, immune regulation and some ongoing clinical trials.

Indexed as

ExosomesAnimalsCell CommunicationHumansMicroRNAsNeoplasmsMicroRNAscancer therapycharacterizationexosomeimmune modulationisolation

Identifiers

PMID39431552
PMCPMC11492151

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.