ArticleJournal of acquired immune deficiency syndromes (1999)2024
Prevalence and Correlates of Frailty Among Older Adults Living With HIV in the CHANGE HIV Cohort.
Article in Journal of acquired immune deficiency syndromes (1999), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prevalence and clinical correlates of frailty among adults with HIV infection and unhealthy alcohol or drug use.AIDS (London, England) · 2026Article
- QR Code-Enabled Self-Access Lifestyle Education in Older People Living With HIV: Pragmatic Pilot Quasi-Experimental Pretest-Posttest Implementation Study.Journal of medical Internet research · 2026Article
- Resilience, and Personality Traits as Independent Correlates of Perceived Treatment Management Abilities in Middle-Aged and Older People Living with HIV.AIDS and behavior · 2026Article
- Self-reported sleep quality and frailty in middle-aged people living with HIV in an African setting: a pilot study.AIDS care · 2026Article
- The interplay of comorbidity, disability, and physical activity among older adults living with HIV: insights from the CHANGE HIV study.BMC geriatrics · 2026Article
- Facilitators and barriers to enhancing cognitive reserve in adults aged ≥ 50 years with HIV-associated mild neurocognitive disorder: a qualitative study.BMC public health · 2025Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvancements in treatment have resulted in improved survival among people living with HIV. However, additional years of life are not necessarily spent in good health, as frailty tends to develop at a younger age among people living with HIV. We set out to examine the prevalence of frailty and its correlates among older adults living with HIV in Canada, with a primary interest in nadir CD4 count.
methodsWe performed a cross-sectional analysis of the Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study, a Canadian cohort of people living with HIV aged 65 years or older. Participants were assessed using the Fried Frailty Phenotype at cohort entry, and those meeting ≥3 criteria were characterized as frail. We used Poisson regression with robust standard errors to estimate the association between nadir CD4 count and frailty, as well as age, gender, time since HIV diagnosis, comorbidities, marital status, and loneliness.
resultsAmong 439 participants included in this analysis (median age 69 years, interquartile ranges 67-73), prevalence of frailty was 16.6%. Frailty was not associated with nadir CD4 count. Not being in a relationship (aRR 2.09, 95% CI 1.01 to 4.30) and greater degree of loneliness (aRR 1.25 per 10 point increase on UCLA loneliness scale, 95% CI 1.09 to 1.44) were associated with frailty.
conclusionsFrailty occurred in 16.6% of older adults living with HIV in this cohort. While nadir CD4 count did not correlate with frailty, being single and lonely did, highlighting the importance of recognizing and addressing these social vulnerabilities among people aging with HIV.
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