ArticleToxicology reports2024
Cardiovascular effects and clinical outcomes in acute opioid toxicity: A case-control study from Port Said and Damietta Governorates Egypt.
Article in Toxicology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Mobitz I Atrioventricular Block Following Combined Opioid and Benzodiazepine Overdose: A Case Report.Cureus · 2026Article
- Evaluating Cardiotoxicity and Factors Associated with In-Hospital Mortality Among Emergency Department Patients with Substance Use Disorder:Sultan Qaboos University medical journal · 2026Observational
- Development of an individualized dementia risk prediction model using deep learning survival analysis incorporating genetic and environmental factors.Alzheimer's research & therapy · 2024Article
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Authors and funding
4 authors.
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Abstract
Substance abuse, particularly opioid intoxication, presents a significant public health challenge, leading to severe cardiovascular complications. This case-control study assessed the cardiac profile and clinical outcomes of 51 patients with confirmed acute opioid toxicity, compared to 51 control participants, in general hospitals across Port Said and Damietta governorates, Egypt. The study revealed that opioid-intoxicated patients exhibited significant cardiovascular abnormalities, including hypotension (39.2 %) and electrocardiogram (ECG) changes (72.5 %), with sinus bradycardia (51 %) being the most common. Additionally, echocardiographic abnormalities were found in 40 % of cases, with abnormal regional wall motion and valvular defects observed in several patients. Elevated levels of cardiac enzymes, such as Troponin-I and CK-MB, were significantly correlated with increased ICU stay length and higher mortality rates. The most common morbidities included coma (64.7 %) and shock (39.2 %). The study underscores the critical need for early cardiac assessment in opioid-intoxicated patients to predict clinical outcomes and guide therapeutic interventions.
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