Double safety guarantees: Food-grade photothermal complex with a pH-triggered NIR absorption from zero to one.

Hongguang Liao, Yanji Chu, Shenglong Liao, Yonglin He, Yingchao Ma, Yapei Wang

Abstract read

In one paragraph

Article in Fundamental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongguang LiaoSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Yanji ChuSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Shenglong LiaoSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Yonglin HeSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Yingchao MaSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Yapei WangSchool of Chemistry and Life Resources, Renmin University of China, Beijing 100872, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photothermal therapy has aroused great attention and showed promising potential in minimally invasive tumor ablation, but the clinical translation is still stifled by the concerns of unwanted injury to normal tissues. The safety concerns might be completely solved only when the two security obstacles of "material-toxicity" and "photo-toxicity" were overcome simultaneously. Herein, a completely non-toxic food-grade photothermal transduction agent (PTA) with double safety guarantees was invented, which shows an absolute transformation of the photothermal effect from "0" to "1" after being triggered by an acidic tumor microenvironment. Inspired by the classical starch-iodine test, a preprogrammed [starch-KI-KIO

Indexed as

Food-gradeNear-infraredPhotothermal therapypH-triggeredStarch-iodine

Identifiers

PMID39431126

DOI10.1016/j.fmre.2022.06.004

PMCPMC11489488

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.