Evidence map›Paper›PMID 39430761›Full record

ArticleFrontiers in immunology2024

SNAP25-induced MYC upregulation promotes high-grade neuroendocrine lung carcinoma progression.

Zhiqiang Chen, Shujing Wang, Jingrui Wang, Ying Wang, Xiangjun Qi, Bo An, Lingling Sun, Lizhu Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiqiang ChenThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Shujing WangThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jingrui WangThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Ying WangThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiangjun QiThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Bo AnDepartment of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Lingling SunDepartment of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Lizhu LinDepartment of Oncology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study investigated the expression and role of Synaptosome associated protein 25 (SNAP25) in high-grade neuroendocrine carcinoma (HGNEC). Methods: We used differentially expressed analysis and weighted gene co-expression network analysis (WGCNA) to identify key genes and modules in HGNEC. KEGG and GO analyses helped understand these genes' roles, and ROC curves assessed their diagnostic value. We also studied SNAP25's relation to immune infiltration and confirmed findings with Results: WGCNA identified 595 key genes related to pathways like MAPK signaling, GABAergic synapse, and cancer-related transcriptional misregulation. Top genes included SNAP25, MYC, NRXN1, GAD2, and SYT1. SNAP25 was notably associated with M2 macrophage infiltration. Dataset GSE40275 confirmed SNAP25's high expression and poor prognosis in HGNEC. qRT-PCR and WB analyses showed increased SNAP25 and c-MYC levels in HGNEC, promoting MEK/ERK pathway activity. Reducing SNAP25 decreased H1299 cell proliferation, migration, invasion, and levels of c-MYC, MEK, and ERK. Finally, Conclusion: SNAP25 regulates c-MYC activation by stimulating the MEK/ERK pathway, ultimately influencing the development of HGNEC.

Indexed as

Carcinoma, NeuroendocrineGene Expression Regulation, NeoplasticLung NeoplasmsProto-Oncogene Proteins c-mycSynaptosomal-Associated Protein 25AnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleHumansMiceMice, NudeNeoplasm GradingPrognosisUp-RegulationMYC protein, humanProto-Oncogene Proteins c-mycSNAP25 protein, humanSynaptosomal-Associated Protein 25c-MycERKhigh-grade neuroendocrine carcinomaMEKsynaptosome associated protein 25

Identifiers

PMID39430761
PMCPMC11486671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.