Evidence map›Paper›PMID 39430740›Full record

ArticleFrontiers in immunology2024

A comparison of haploidentical versus HLA-identical sibling outpatient hematopoietic cell transplantation using reduced intensity conditioning in patients with acute leukemia.

José Carlos Jaime-Pérez, Jorge Valdespino-Valdes, Andrés Gómez-De León, Renata Valeria Barragán-Longoria, Adriana Dominguez-Villanueva, Olga Graciela Cantú-Rodríguez, César Homero Gutiérrez-Aguirre, David Gómez-Almaguer

Abstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

José Carlos Jaime-PérezHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Jorge Valdespino-ValdesHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Andrés Gómez-De LeónHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Renata Valeria Barragán-LongoriaHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Adriana Dominguez-VillanuevaHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Olga Graciela Cantú-RodríguezHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
César Homero Gutiérrez-AguirreHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
David Gómez-AlmaguerHematology Department, Internal Medicine Division, Dr. José E. González University Hospital, School of Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hematopoietic cell transplantation (HCT) increases survival for acute leukemia. Outpatient allogeneic HCT reduces costs and increases transplant rates in developing countries. We report outcomes of outpatient HLA-identical and haploidentical HCT in acute leukemia. Methods: This single-center retrospective cohort study analyzed 121 adult patients with acute myeloblastic (AML) and acute lymphoblastic leukemia (ALL) receiving an outpatient allogeneic HCT with peripheral blood allografts after reduced-intensity conditioning (RIC) from 2012-2022. Results: There were 81 (67%) haploidentical and 40 (33%) HLA-identical transplants. Complete chimerism (CC) at day +100 was not different in HLA-identical compared to haploidentical HCT (32.5% and 38.2%, Conclusions: Outpatient peripheral blood allogenic HCT after RIC is a valid and effective alternative for adult patients suffering acute myeloblastic or lymphoblastic leukemia in low-income populations.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationPrecursor Cell Lymphoblastic Leukemia-LymphomaSiblingsTransplantation ConditioningTransplantation, HaploidenticalAdolescentAdultAgedFemaleHLA AntigensHumansLeukemia, Myeloid, AcuteMaleMiddle AgedOutpatientsHLA Antigensacute lymphoblastic leukemiaacute myeloblastic leukemiahematopoietic cell transplantLatin Americaoutpatient transplantationperipheral blood transplantreduced-intensity conditioning

Identifiers

PMID39430740
PMCPMC11486716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.