Evidence map›Paper›PMID 39430616›Full record

ArticleEClinicalMedicine2024

Multivariable models of outcomes with [

Ken Herrmann, Andrei Gafita, Johann S de Bono, Oliver Sartor, Kim N Chi, Bernd J Krause, Kambiz Rahbar, Scott T Tagawa, Johannes Czernin, Ghassan El-Haddad and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511664 (VISION), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511664 phase3completednot on this map

VISION: An International, Prospective, Open Label, Multicenter, Randomized Phase 3 Study of 177Lu-PSMA-617 in the Treatment of Patients With Progressive PSMA-positive Metastatic Castration-resistant Prostate Cancer (mCRPC)

TypeinterventionalSponsorEndocyteRan2018 to 2023Enrolled861ConditionsProstate CancerArms177Lu-PSMA-617, Best supportive/best standard of care
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Outcomes of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Baseline PSMA PET/CT Biomarkers for Patient Selection in [Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Prompt PSA changes as a prognostic marker for response to PSMA-radioligand therapy.European journal of nuclear medicine and molecular imaging · 2026
    Article
  9. Article
  10. Fully automated volumetric assessment of tumor burden using artificial intelligence onEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  11. Combination therapy strategies in engineeredCell communication and signaling : CCS · 2026
    Review
  12. Article
  13. Article
  14. Article
  15. Molecules (Basel, Switzerland) · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ken HerrmannDepartment of Nuclear Medicine, University of Duisburg-Essen and German Cancer Consortium (DKTK), Essen University Hospital, Essen, Germany.
Andrei GafitaDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johann S de BonoDivision of Clinical Studies, The Institute of Cancer Research and the Royal Marsden Hospital, London, UK.
Oliver SartorDepartment of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Kim N ChiDivision of Medical Oncology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Bernd J KrauseDepartment of Nuclear Medicine, Rostock University Medical Center, Rostock, Germany.
Kambiz RahbarDepartment of Nuclear Medicine, Münster University Hospital, Münster, Germany.
Scott T TagawaDepartment of Medicine, Division of Hematology and Medical Oncology and Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Johannes CzerninAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology and Institute of Urologic Oncology, University of California Los Angeles, Los Angeles, CA, USA.
Ghassan El-HaddadDepartment of Diagnostic Imaging and Interventional Radiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Connie C WongNovartis Pharmaceuticals Corporation, Cambridge, MA, USA.
Zhaojie ZhangNovartis Pharmaceuticals Corporation, Cambridge, MA, USA.
Celine WilkeNovartis Pharma AG, Basel, Switzerland.
Osvaldo MiranteAdvanced Accelerator Applications, A Novartis Company, Geneva, Switzerland.
Michael J MorrisGenitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Karim FizaziMedical Oncology Department, Institut Gustave Roussy, University of Paris-Saclay, Villejuif, France.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Background: [ Methods: Adults with progressive post androgen receptor pathway inhibitor and taxane prostate-specific membrane antigen (PSMA)-positive mCRPC received Findings: Patients were randomised between June 2018 and October 2019. Data from all 551 patients in the Interpretation: These models of outcomes with Funding: Novartis.

Indexed as

177Lu-PSMA-617mCRPCNomogramOverall survivalPSA responseRadiographic progression-free survivalVISION trial

Identifiers

PMID39430616
PMCPMC11490806

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.