Evidence map›Paper›PMID 39430393›Full record

ReviewNeuro-oncology advances2024

Clinical, molecular, and genetic features of spinal meningiomas.

Dylan Deska-Gauthier, Laureen D Hachem, Justin Z Wang, Alex P Landry, Leeor Yefet, Chloe Gui, Yosef Ellengbogen, Jetan Badhiwala, Gelareh Zadeh, Farshad Nassiri

Abstract readReview
In one paragraph

Review in Neuro-oncology advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dylan Deska-GauthierFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Laureen D HachemDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Justin Z WangDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Alex P LandryDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Leeor YefetDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Chloe GuiDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Yosef EllengbogenDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Jetan BadhiwalaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Gelareh ZadehPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
Farshad NassiriPrincess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

Funding

Establishing the clinical utility of cell-free tumor DNA methylation profiling as a reliable liquid biopsy approach in brain tumorsR01CA263196 · NCI · UNIVERSITY HEALTH NETWORK · PI Daniel De Carvalho, Gelareh Zadeh · 2022 to 2026
$1.9M
NCI NIH HHS R01 CA263196
6 · The paper itself

Abstract

Spinal meningiomas comprise 25%-46% of all primary spinal tumors. While the majority are benign and slow-growing, when left untreated, they can result in significant neurological decline. Emerging clinical, imaging, and molecular data have begun to reveal spinal meningiomas as distinct tumor subtypes compared to their intracranial counterparts. Moreover, recent studies indicate molecular and genetic subtype heterogeneity of spinal meningiomas both within and across the classically defined WHO grades. In the current review, we focus on recent advances highlighting the epidemiological, pathological, molecular/genetic, and clinical characteristics of spinal meningiomas. Furthermore, we explore patient and tumor-specific factors that predict prognosis and postoperative outcomes. We highlight areas that require further investigation, specifically efforts aimed at linking unique molecular, genetic, and imaging characteristics to distinct clinical presentations to better predict and manage patient outcomes.

Indexed as

genomicsmeningiomamolecularoncologyspine

Identifiers

PMID39430393
PMCPMC11485713

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.