Evidence map›Paper›PMID 39430255›Full record

ArticleInternational journal of biological sciences2024

AFM41a: A Novel PAD2 Inhibitor for Sepsis Treatment-Efficacy and Mechanism.

Tao Dong, Leonard Barasa, Xin Yu, Wenlu Ouyang, Liujiazi Shao, Chao Quan, Su He Wang, Jifeng Zhang, Morgan Salmon, Allan Tsung and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tao DongDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Leonard BarasaProgram in Chemical Biology, Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Xin YuDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Wenlu OuyangDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Liujiazi ShaoDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Chao QuanDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
Su He WangInternal Medicine, Division of Allergy, University of Michigan Health System, Ann Arbor, MI, USA.
Jifeng ZhangDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Morgan SalmonDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, MI, USA.
Allan TsungDepartment of Surgery, Division of Surgical Science, University of Virginia, Charlottesville, VA 22903, USA.
Hasan B AlamDepartment of Surgery, Northwestern University, Arkes Pavilion, 676 N St Clair St Ste 2320, Chicago, IL 60611, USA.
Jianjie MaDepartment of Surgery, Division of Surgical Science, University of Virginia, Charlottesville, VA 22903, USA.
Paul R ThompsonProgram in Chemical Biology, Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Yongqing LiDepartment of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.

Funding

Chemical probes to decipher PAD biologyR35GM118112 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Paul R Thompson · 2016 to 2026
$9.5M
Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's diseaseR01AG072430 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma · 2022 to 2026
$3.4M
MG53 function in muscle agingR01AG071676 · NIA · UNIVERSITY OF VIRGINIA · PI Jianjie Ma, Ki Ho Park · 2022 to 2026
$3.1M
Protein therapy to treat virus induced cardiopulmonary injuryR01HL157215 · NHLBI · UNIVERSITY OF VIRGINIA · PI CAI, CHUANXI, MA, JIANJIE · 2022 to 2025
$2.7M
PAD2 and CitH3 in Pathogenesis of Sepsis-induced ALIR01HL155116 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALAM, HASAN B, LI, YONGQING · 2021 to 2024
$2.1M
NHLBI NIH HHS R01 HL155116NHLBI NIH HHS R01 HL157215NIA NIH HHS R01 AG071676NIA NIH HHS R01 AG072430NIGMS NIH HHS R35 GM118112
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

SepsisAnimalsExtracellular TrapsMacrophagesMaleMiceMice, Inbred C57BLProtein-Arginine Deiminase Type 2Pseudomonas aeruginosaPseudomonas InfectionsPadi2 protein, mouseProtein-Arginine Deiminase Type 2AFM41aautophagymacrophage polarizationPseudomonas aeruginosa

Identifiers

PMID39430255
PMCPMC11488583

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.