Evidence map›Paper›PMID 39430222›Full record

ArticlePNAS nexus2024

Self-regulated analgesia in males but not females is mediated by endogenous opioids.

Jon G Dean, Mikaila Reyes, Valeria Oliva, Lora Khatib, Gabriel Riegner, Nailea Gonzalez, Grace Posey, Jason Collier, Julia Birenbaum, Krishnan Chakravarthy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Pandora's Box.BJPsych international · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jon G DeanDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.ORCID https://orcid.org/0000-0003-3834-1524
Mikaila ReyesDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.ORCID https://orcid.org/0009-0007-4682-0775
Valeria OlivaDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Lora KhatibDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Gabriel RiegnerDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Nailea GonzalezDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Grace PoseyDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
Jason CollierDepartment of Neurobiology and Anatomy, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.
Julia BirenbaumDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Krishnan ChakravarthyDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.
Rebecca E WellsDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.ORCID https://orcid.org/0000-0002-9860-3699
Burel GoodinDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, NC 27109, USA.ORCID https://orcid.org/0000-0002-8159-1310
Roger FillingimDepartment of Community Dentistry and Behavioral Science, The University of Florida, Gainesville, FL 32611, USA.
Fadel ZeidanDepartment of Anesthesiology, University of California San Diego, La Jolla, CA 92013, USA.ORCID https://orcid.org/0000-0002-4310-1325

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Online TEAM Migraine: Online Techniques and Education Aimed to Manage MigraineR01AT011502 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Rebecca Erwin Wells · 2022 to 2026
$3.2M
Brain Mechanisms Supporting Mindfulness Meditation-Based Chronic Pain ReliefR01AT009693 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ZEIDAN, FADEL · 2018 to 2023
$2.1M
The role of endogenous opioids in mindfulness-based chronic pain reliefR21AT010352 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZEIDAN, FADEL · 2019 to 2020
$433k
Brain Mechanisms Supporting Mindfulness Meditation-Induced Pain and Stress ReliefF32AT012587 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEAN, JON GREGORY · 2023 to 2025
$226k
NCATS NIH HHS UL1 TR001442NCCIH NIH HHS F32 AT012587NCCIH NIH HHS R01 AT009693NCCIH NIH HHS R01 AT011502NCCIH NIH HHS R21 AT010352
6 · The paper itself

Abstract

Converging lines of preclinical and clinical research indicate that females, in stark contrast to males, display an increased prevalence of chronic pain. Females also demonstrate weaker analgesic efficacy in response to opioid therapies when compared with males. These sex-specific differences may be driven by dimorphic endogenous opioidergic responses. In rodent models, analgesia exhibited in males but not females was reversed by inhibiting endogenous opioidergic reception. In humans, the sex-specific endogenous system(s) supporting the direct attenuation of evoked pain has not been identified. To determine whether opioidergic blockade reverses self-regulated analgesia in males as compared to females, the present study combined two operationally analogous clinical trials (

Identifiers

PMID39430222
PMCPMC11489871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.