ReviewRSC medicinal chemistry2024
The role of silicon in drug discovery: a review.
Review in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Deoxygenative functionalization of alcohols, ethers, and carbonyl compounds by chromium catalysis.Science advances · 2026Article
- Chemically Interpretable Prediction Models for Silicon and Germanium Bond Dissociation Enthalpies.ACS omega · 2026Article
- Stereoselective Substituted Oxasilinane Synthesis from Diallylsilanes via Electrophile-Promoted Rearrangement, RCM, and Re-Catalyzed Allylic Transposition.The Journal of organic chemistry · 2026Article
- Nickel/Photoredox Dual-Catalyzed Migratory Reductive C(spAngewandte Chemie (International ed. in English) · 2026Article
- Incorporation of Organosilicon Motifs in Natural and Synthetic Small Molecules for Anticancer Therapeutics: Current Perspectives and Future Opportunities in Drug Design.Molecules (Basel, Switzerland) · 2026Review
- Crystalline Silaspiropentane and Its Rearrangement to Silacyclobutane.Organic letters · 2026Article
- Solvent-temperature coupled hydride transfer controls product selectivity in the HSiRChemical science · 2026Article
- Deprotonative C(spAngewandte Chemie (International ed. in English) · 2026Article
- Cobalt-Catalyzed Intramolecular C─H Silylation of Arenes.Angewandte Chemie (International ed. in English) · 2026Article
- Multispectroscopic Investigation of the Organosilyl EtherThe journal of physical chemistry. A · 2026Article
- Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins.JACS Au · 2026Article
- A novel 14-deoxy-12-hydroxyandrographolide analogue promotes apoptosis in colorectal cancer through ROS-dependent endoplasmic reticulum stress activation.Discover oncology · 2026Article
- Metalloids: Semi as Metals yet Full of Antimicrobial Potential.ChemMedChem · 2026Review
- Photoinduced Generation of (Boryl)Silyl and (Chloro)Silyl Radicals: Access to Trisubstituted Silylboranes and Chlorosilanes.Angewandte Chemie (International ed. in English) · 2026Article
- Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Blue Fluorescent Siloxytecans Exhibit Potent Anticancer Activity and Enable Direct Real-Time Quantification of Intracellular Uptake.ACS bio & med chem Au · 2026Article
- Synthetic cannabinoid receptor agonists containing silicon: exploring the metabolic pathways of ADMB- and Cumyl-3TMS-PrINACA in human urine specimens and post mortem material compared to in vitro and in silico data.Archives of toxicology · 2026Article
- Chemical finger-printing, antioxidant activity and in silico validation of phytometabolites of Octhochloa compressa.Scientific reports · 2025Article
- Photo-Mediated Silacyclization by Wavelength-Dependent Selective C─F or C─H Functionalization.Angewandte Chemie (International ed. in English) · 2025Article
- Evaluating the Aqueous Stability of Alkyl-/Aryl-Hydrosilanes by NMR Spectroscopy and GC-MS.ChemPlusChem · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are often regarded as being similar with silicon located directly beneath carbon in the same group in the periodic table. That being noted, in many instances a clear dichotomy also exists between silicon and carbon, and these differences often lead to vastly different physiochemical and biological properties. As a result, the utility of silicon in drug discovery has attracted significant attention and has grown rapidly over the past decade. This review showcases some recent advances in synthetic organosilicon chemistry and examples of the ways in which silicon has been employed in the drug-discovery field.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.