Evidence map›Paper›PMID 39430000›Full record

ArticleLaryngoscope investigative otolaryngology2024

Impact of implementing stricter criteria for blood transfusion in patients with head and neck cancer undergoing free tissue transfer.

Osama A Hamdi, Deepa Danan, Amber Denner, Jeffrey R Bellinger, Noah Thornton, David C Shonka, Jonathan C Garneau, Katherine Fedder, Mark J Jameson, Eric M Dowling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Osama A HamdiDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Deepa DananDepartment of Otolaryngology-Head and Neck Surgery University of Florida Gainesville Florida USA.
Amber DennerDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Jeffrey R BellingerDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.ORCID https://orcid.org/0000-0003-3470-0024
Noah ThorntonDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
David C ShonkaDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Jonathan C GarneauDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Katherine FedderDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Mark J JamesonDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.
Eric M DowlingDepartment of Otolaryngology-Head and Neck Surgery University of Virginia Charlottesville Virginia USA.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Muscle progenitor cell-based implants for dynamic laryngeal muscle reconstructionR01DC014070 · NIDCD · PURDUE UNIVERSITY · PI HALUM, STACEY L. · 2015 to 2024
$4.9M
Cellular Reinnervation Therapy for Vocal Fold ParalysisR01DC019632 · NIDCD · INDIANA UNIVERSITY INDIANAPOLIS · PI HALUM, STACEY L., VOYTIK-HARBIN, SHERRY L · 2021 to 2025
$3.2M
NCATS NIH HHS UL1 TR002529NIDCD NIH HHS R01 DC014070NIDCD NIH HHS R01 DC019632
6 · The paper itself

Abstract

Objective: Recent literature studying the impact of blood transfusion on outcomes in patients with head and neck cancer (HNC) have shown that blood transfusions are associated with increased risk of death and higher wound infection rates. The purpose of this study was to implement a lower transfusion threshold while comparing outcomes of free flap patients following initiation of a new transfusion guideline. Methods: A retrospective study of all patients at a tertiary care academic center who underwent free tissue transfer after HNC resection between July 17, 2007 and June 7, 2021. Transfusion criteria were adjusted in 2014; the hematocrit threshold to transfuse was incrementally reduced from 30% in 2007 to 21% in 2017. The main outcomes of interest were overall survival (OS) and recurrence free survival (RFS). Results: A total of 346 patients met the criteria for inclusion in the study. Groups 1 (less strict protocol - 30%) and 2 (stricter protocol - 21%) consisted of 171 and 175 patients, respectively. Fewer units of packed red cells were transfused per patient in group 2 (0.26 vs. 2.87 in group 1, Conclusion: In HNC patients undergoing free tissue transfer, stricter transfusion criteria with threshold hematocrit of 21% was associated with improved OS, RFS, and complication rates with no negative impact on free flap survival. Level of Evidence: Level IV.

Indexed as

blood transfusionfree flapfree tissue transfertransfusion protocol

Identifiers

PMID39430000
PMCPMC11487678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.