Evidence map›Paper›PMID 39429966›Full record

ReviewThe Lancet regional health. Europe2024

COVID-19 and multiple sclerosis: challenges and lessons for patient care.

Luca Prosperini, Georgina Arrambide, Elisabeth G Celius, Delia Goletti, Joep Killestein, Daphne Kos, Luigi Lavorgna, Celine Louapre, Maria Pia Sormani, Dominika Stastna and 2 more

Abstract readReview
In one paragraph

Review in The Lancet regional health. Europe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luca ProsperiniMS Centre, Department of Neurosciences, S. Camillo-Forlanini Hospital, Rome, Italy.
Georgina ArrambideNeurology-Neuroimmunology Department Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d'Hebron Barcelona Hospital Campus, Universitat Autònoma de Barcelona, Barcelona, Spain.
Elisabeth G CeliusDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani", Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
Joep KillesteinDepartment of Neurology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Daphne KosNational Multiple Sclerosis Center, Melsbroek, Belgium.
Luigi LavorgnaDAI Internal Medicine, Geriatric and Neurology, University Hospital "Luigi Vanvitelli", Naples, Italy.
Celine LouapreSorbonne Université, Paris Brain Institute-ICM, CIC Neurosciences, Hôpital de la Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, INSERM, CNRS, FCRIN4MS, Paris, France.
Maria Pia SormaniDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Dominika StastnaDepartment of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University in Prague and General University Hospital, Prague, Czechia.
Tjalf ZiemssenCenter of Clinical Neuroscience, Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.
Massimiliano Di FilippoSection of Neurology, Department of Medicine and Surgery, University of Perugia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the COVID-19 pandemic, people with multiple sclerosis (MS) and their healthcare providers have faced unique challenges related to the interaction between SARS-CoV-2, underlying neurological disease and the use of disease-modifying treatments (DMTs). Key concerns arose, primarily related to the possibility that SARS-CoV-2 infection could trigger the initial demyelinating event or exacerbate disease activity. Another major concern was the safety and efficacy of the COVID-19 vaccines, especially for patients undergoing specific treatments that could weaken their antibody responses. In the post-infection phase, identifying long COVID in patients with MS has been complicated due to the large overlap between post-infection sequelae and MS symptoms. In addition, disruptions in health and rehabilitation services have made it difficult for MS patients to access care. This Series article explores current evidence on the interaction between MS and SARS-CoV-2, identifies the challenges posed by the COVID-19 pandemic in the care of patients with MS, and discusses the significant adoption of digital health solutions, including telemedicine and new technology-based rehabilitation approaches. Based on lessons learned, recommendations and future directions are offered for managing patients with MS, rethinking healthcare systems and improving health outcomes in the post-COVID-19 pandemic era.

Indexed as

COVID-19Multiple sclerosisSARS-CoV-2

Identifiers

PMID39429966
PMCPMC11486927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.