Evidence map›Paper›PMID 39429940›Full record

ArticleRSC advances2024

Cu-doped calcium phosphate supraparticles for bone tissue regeneration.

Anika Höppel, Olivia Bahr, Regina Ebert, Annette Wittmer, Michael Seidenstuecker, M Carolina Lanzino, Uwe Gbureck, Sofia Dembski

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anika HöppelDepartment Tissue Engineering and Regenerative Medicine (TERM), University Hospital Würzburg 97070 Würzburg Germany anika.hoeppel@isc-extern.fraunhofer.de.ORCID https://orcid.org/0009-0004-7968-3509
Olivia BahrDepartment of Musculoskeletal Tissue Regeneration, University of Würzburg 97074 Würzburg Germany.ORCID https://orcid.org/0009-0004-9226-1722
Regina EbertDepartment of Musculoskeletal Tissue Regeneration, University of Würzburg 97074 Würzburg Germany.ORCID https://orcid.org/0000-0002-8192-869X
Annette WittmerMedical Center University of Freiburg, Faculty of Medicine, Institute for Microbiology and Hygiene 79104 Freiburg Germany.
Michael SeidenstueckerG.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Faculty of Medicine, Albert-Ludwigs-University of Freiburg 79106 Freiburg Germany.
M Carolina LanzinoInstitute for Manufacturing Technologies of Ceramic Components and Composites (IFKB), University of Stuttgart 70569 Stuttgart Germany.
Uwe GbureckDepartment for Functional Materials in Medicine and Dentistry, University of Würzburg 97070 Würzburg Germany.
Sofia DembskiDepartment Tissue Engineering and Regenerative Medicine (TERM), University Hospital Würzburg 97070 Würzburg Germany anika.hoeppel@isc-extern.fraunhofer.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium phosphate (CaP) minerals have shown great promise as bone replacement materials due to their similarity to the mineral phase of natural bone. In addition to biocompatibility and osseointegration, the prevention of infection is crucial, especially due to the high concern of antibiotic resistance. In this context, a controlled drug release as well as biodegradation are important features which depend on the porosity of CaP. An increase in porosity can be achieved by using nanoparticles (NPs), which can be processed to supraparticles, combining the properties of nano- and micromaterials. In this study, Cu-doped CaP supraparticles were prepared to improve the bone substitute properties while providing antibacterial effects. In this context, a modified sol-gel process was used for the synthesis of CaP NPs, where a Ca/P molar ratio of 1.10 resulted in the formation of crystalline β-tricalcium phosphate (β-TCP) after calcination at 1000 °C. In the next step, CaP NPs with Cu

Identifiers

PMID39429940
PMCPMC11483895

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.