Evidence map›Paper›PMID 39429876›Full record

ArticleiMeta2024

The rheumatoid arthritis gut microbial biobank reveals core microbial species that associate and effect on host inflammation and autoimmune responses.

Hao-Jie Huang, Chang Liu, Xin-Wei Sun, Rui-Qi Wei, Ling-Wei Liu, Hao-Yu Chen, Rashidin Abdugheni, Chang-Yu Wang, Xiao-Meng Wang, He Jiang and 11 more

Abstract read
In one paragraph

Article in iMeta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Epithelial Inflammatory iNOS-Nitrate Axis EnhancesInternational journal of molecular sciences · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. [Gut-brain-joint axis in rheumatoid arthritis: from microeco-logical disturbance to multi-target synergy].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
  7. Article
  8. Forecasting Root Rot Disease through Predictive Microbial Functional Profiling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Proposal of two novel species,International journal of systematic and evolutionary microbiology · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hao-Jie HuangState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Chang LiuState Key Laboratory of Microbial Technology Shandong University Qingdao China.ORCID 0000-0001-9398-3701
Xin-Wei SunState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Rui-Qi WeiState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Ling-Wei LiuDepartment of Rheumatology The Affiliated Hospital of Qingdao University Qingdao China.
Hao-Yu ChenState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Rashidin AbdugheniState Key Laboratory of Desert and Oasis Ecology, Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences Ürűmqi China.
Chang-Yu WangSchool of Life Sciences, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China.
Xiao-Meng WangState Key Laboratory of Microbial Technology Shandong University Qingdao China.
He JiangState Key Laboratory of Microbial Technology Shandong University Qingdao China.ORCID 0000-0001-7326-8882
Han-Yu NiuCollege of Veterinary Medicine Shanxi Agricultural University Taigu China.
Li-Juan FengState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Jia-Hui HeCollege of Veterinary Medicine Shanxi Agricultural University Taigu China.
Yu JiangState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Yan ZhaoBiomedical Sciences College & Shandong Medicinal Biotechnology Centre Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China.
Yu-Lin WangState Key Laboratory of Microbial Technology Shandong University Qingdao China.ORCID 0000-0002-9899-7712
Qiang ShuDepartment of Rheumatology Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan China.
Ming-Xia BiState Key Laboratory of Microbial Technology Shandong University Qingdao China.
Lei ZhangState Key Laboratory of Microbial Technology Shandong University Qingdao China.ORCID 0000-0003-4284-2604
Bin LiuDepartment of Rheumatology The Affiliated Hospital of Qingdao University Qingdao China.
Shuang-Jiang LiuState Key Laboratory of Microbial Technology Shandong University Qingdao China.ORCID 0000-0002-7585-310X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota dysbiosis has been implicated in rheumatoid arthritis (RA) and influences disease progression. Although molecular and culture-independent studies revealed RA patients harbored a core microbiome and had characteristic bacterial species, the lack of cultured bacterial strains had limited investigations on their functions. This study aimed to establish an RA-originated gut microbial biobank (RAGMB) that covers and further to correlates and validates core microbial species on clinically used and diagnostic inflammation and immune indices. We obtained 3200 bacterial isolates from fecal samples of 20 RA patients with seven improved and 11 traditional bacterial cultivation methods. These isolates were phylogenetically identified and selected for RAGMB. The RAGMB harbored 601 bacterial strains that represented 280 species (including 43 novel species) of seven bacterial phyla. The RAGMB covered 93.2% at species level of medium- and high-abundant (relative abundances ≥0.2%) RA gut microbes, and included four rare species of the phylum

Indexed as

core microbial speciesEubacterium rectaleinflammatory and immune responsesMediterraneibacter tenuisRA clinical indicesRA‐originated gut microbial biobank (RAGMB)rheumatoid arthritis (RA)

Identifiers

PMID39429876
PMCPMC11487554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.