Evidence map›Paper›PMID 39429668›Full record

ArticleIranian journal of public health2024

Association between Age and Miscarriage in an Assisted Reproductive Technology Population: A 10-Year Cohort Study.

Doudou Zhao, Jie Chen, Xiayang Li, Zhaofang Li, Jingchen Zhang, Caixia Gao, Wenbo Hong, Danmeng Liu, Wenhao Shi, Juanzi Shi and 1 more

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Article in Iranian journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Doudou ZhaoTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Jie ChenDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Xiayang LiDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Zhaofang LiDepartment of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, China.
Jingchen ZhangGraduate Department, Xi'an Medical University, Xi'an, Shaanxi, 710021, China.
Caixia GaoGraduate Department, Xi'an Medical University, Xi'an, Shaanxi, 710021, China.
Wenbo HongGraduate Department, Xi'an Medical University, Xi'an, Shaanxi, 710021, China.
Danmeng LiuTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Wenhao ShiTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Juanzi ShiTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.
Pengfei QuTranslational Medicine Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Advanced maternal age decreased success of pregnancy rate in the assisted reproductive technology (ART) treatment. We aimed to investigate the association between age and miscarriages in women who required ART for conception. Methods: A cohort study was conducted using a 10-year sample of 14,898 pregnancy cycles with ART treatment in Xi'an, China. The effects of women's age on miscarriage were assessed using Poisson regression models. The threshold effect between age and miscarriage was explored through curve fitting. Results: Compared with lower than 30 years, the risks of early miscarriage and miscarriage were higher in the older age groups (early miscarriage: [35-37 years: RR=1.48, 95% confidence interval (CI): 1.26 to 1.74; ≥38 years: RR=2.25, 95% CI: 1.87 to 2.72]; miscarriage: [35-37 years: RR=1.45, 95%CI: 1.24 to 1.69; ≥38 years: RR=2.17, 95%CI: 1.82 to 2.60]). The nonlinear relationship between age and early miscarriage and miscarriages were observed. The risk of early miscarriage and miscarriage rapidly increased with age after the turning point (age=33 years) (<33 years: [early miscarriage: RR=1.02, 95% CI: 1.00 to 1.04; miscarriage: RR=1.02, 95% CI: 1.00 to 1.03]; ≥33 years: [early miscarriage: RR=1.11, 95% CI: 1.08 to 1.13; miscarriage: RR=1.10, 95% CI: 1.07 to 1.13]). Conclusion: Among pregnancy cycles undergoing ART, advanced age is associated with higher risk of early miscarriage and miscarriage, and nonlinear relationship between age and early miscarriage and miscarriage were found. More attention should be paid to the risk of pregnant women with older than 33 years in ART treatment.

Indexed as

Advanced ageAssisted reproductive technologyChinese populationCohort studyMiscarriage

Identifiers

PMID39429668
PMCPMC11490329

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