Evidence map›Paper›PMID 39429505›Full record

ArticleSciBase hematology & blood disorders2024

Influences on the Hematopoietic Stem Cell Niche.

Weiyuan Wang, Timothy J Brown, Brian M Barth

Abstract read
In one paragraph

Article in SciBase hematology & blood disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effects of exosomes from different origins on osteoclasts.Journal of orthopaedic surgery and research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Weiyuan WangDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta GA 30322 USA.ORCID 0000-0003-0009-0467
Timothy J BrownDivision of Hematology and Oncology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas TX 75390 USA.ORCID 0000-0002-4843-4639
Brian M BarthDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824 USA.ORCID 0000-0002-3542-1804

Funding

The Administrative CoreP20GM103395 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI BRIAN M BARNES · 2012 to 2026
$66.1M
TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
Tissue Repository and Animal Models CoreP01CA171983 · NCI · UNIVERSITY OF VIRGINIA · PI LOUGHRAN, THOMAS P. · 2013 to 2024
$19.9M
CANCER CLINICAL EPIDEMIOLOGY TRAINING GRANTT32CA009679 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Richard Aplenc, Karen Glanz · 1992 to 2026
$11.1M
Regulation of Ceramide-Based Therapeutics in Acute Myeloid LeukemiaK22CA190674 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2016 to 2018
$485k
Combinatorial Decitabine and Liposomal Ceramide for Acute Myeloid LeukemiaR03CA252825 · NCI · UNIVERSITY OF NEW HAMPSHIRE · PI BARTH, BRIAN MICHAEL · 2020 to 2020
$151k
NCI NIH HHS K22 CA190674NCI NIH HHS L30 CA274783NCI NIH HHS P01 CA171983NCI NIH HHS R03 CA252825NCI NIH HHS T32 CA009679NIGMS NIH HHS P20 GM103395NIGMS NIH HHS P20 GM113131
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) are supported by the bone marrow microenvironment to maintain normal production of blood cells. The niche may be considered an "ecosystem" that support the function of HSCs and other supportive cells. Alterations in the bone marrow niche are commonly observed in hematologic malignancies. Here, we review recent insights into the location and the molecular and cellular components of the bone marrow niche. Moreover, we discuss how the niche interacts with HSCs to drive the pathogenesis of hematopoietic malignancies. Overall, a better understanding of the influences on the HSC niche may drive therapeutic development targeting defective and aberrant hematopoiesis.

Indexed as

acute myeloid leukemiaangiogeninbone marrowCXCL12G-CSFhematopoietic stem cellsmesenchymal stem cellsmetabolismmicroenvironmentmyelodysplastic syndromenichestem cell factorthrombopoietin

Identifiers

PMID39429505
PMCPMC11486556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.