ArticleCureus2024
Effect of Alpha Hydroxy Acids as Dentin Conditioning Agents on Growth Factor Release: An In Vitro Study.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe study aimed to evaluate the effects of alpha hydroxy acids and chelating agents on dentin conditioning for the release of growth factors.
methodsThe agents used for dentin conditioning included 17% ethylenediaminetetraacetic acid (EDTA), 10% glycolic acid (GA), 10% citric acid (CA), and 5% maleic acid (MA). Forty horizontally sectioned (SV1) human dentine slices were conditioned for 5 and 10 minutes so that the growth factor liberation reached quantifiable levels. Transforming growth factor beta-1 (TGF-β1) release and surface exposure were quantified by enzyme-linked immunosorbent assay (ELISA). Growth factor measurement required immediately removing the solutions from each of the 48-well plates (with consistent dentine surface area and weight) and freezing at -20°C so that ELISA measured the growth factors.
resultsAfter 5-min conditioning of dentine slices, CA was the most effective agent for growth factor release into the aqueous environment as measured by ELISA (post hoc Tukey's test p<0.05). Furthermore, dentine slices subjected to GA treatment for the same duration of time showed noticeably lower surface levels of TGF-β1 in comparison to the other agents employed.
conclusionsBased on the findings of this in vitro study, a desirable biological growth factor-mediated effect may be gained when conditioning dentin with milder acidic or chelating agents such as CA, MA, and EDTA.
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