Evidence map›Paper›PMID 39429250›Full record

ArticleAdvanced therapeutics2024

Single-Administration Self-Boosting Microneedle Patch for The Treatment of Obesity.

Parbeen Singh, Tra Vinikoor, Nidhi Sharma, Nicole Nelson, Somasundaram Prasadh, Ralph Oiknine, Thanh Duc Nguyen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Parbeen SinghDepartment of Mechanical Engineering, University of Connecticut, United States.
Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Nidhi SharmaDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Nicole NelsonDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA.
Somasundaram PrasadhDepartment of Mechanical Engineering, University of Connecticut, United States.
Ralph OiknineRalph Oiknine MD. ALJ Creative works LLC.
Thanh Duc NguyenDepartment of Mechanical Engineering, University of Connecticut, United States.

Funding

Regenerative Engineering of Musculoskeletal Tissues- a Convergence Doctoral Training ProgramT32AR079114 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LAURENCIN, CATO T. · 2021 to 2025
$1.1M
Single-administration microneedles with controlled sustained release of non-opioid analgesics to treat osteoarthritis painR21AR080919 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2022 to 2023
$474k
NIAMS NIH HHS R21 AR080919NIAMS NIH HHS T32 AR079114
6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are one of the most effective treatments for obesity. The current therapy associated with repeated subcutaneous injections to maintain the drug therapeutic effect causes patient compliance issues and raises environmental concerns (due to sharp biohazard waste from disposed syringes/needles). Herein, we report a programmable scheduled release microneedles (PSR-MNs) system for delivering Semaglutide (a GLP-1 RA agent with a half-life of ~ 7 days) to manage and treat obesity. A single skin administration of a PSR-MNs patch (2 cm × 2 cm) which contains 4 programmable core-shell MNs patches (1 cm

Indexed as

GLP-1 therapyobesity treatmentProgrammed Scheduled MNs

Identifiers

PMID39429250
PMCPMC11486425

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.