Evidence map›Paper›PMID 39429239›Full record

ArticleJACC. Advances2024

Characteristics and Outcomes of Patients With Valvular Cardiogenic Shock.

Raunak M Nair, Sanchit Chawla, Feras Alkhalaileh, Bahaa Abdelghaffar, Agam Bansal, Andrew Higgins, Ran Lee, Penelope Rampersad, Umesh N Khot, Wael A Jaber and 3 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309029 (PROspective Evaluation of Pre-empTive Left Atrial Venoarterial Extra-Corporeal Membrane oxygenaTion for Complex High-risk Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07309029 recruitingnot on this mapstarted 2026, after this paper: background citation

PROspective Evaluation of Pre-empTive Left Atrial Venoarterial Extra-Corporeal Membrane oxygenaTion for Complex High-risk Transcatheter Aortic Valve Replacement: PROTECT-TAVR

Typeobservational_patient_registrySponsorAtlantic Health SystemRan2026 to 2027Enrolled30ConditionsSevere Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve ImplantationArmsLeft Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation In Valvular Cardiogenic Shock.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Raunak M NairCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Sanchit ChawlaCleveland Clinic Critical Care Department, Cleveland, OH, USA.
Feras AlkhalailehCleveland Clinic Foundation Internal Medicine Department, Cleveland, OH, USA.
Bahaa AbdelghaffarCleveland Clinic Foundation Internal Medicine Department, Cleveland, OH, USA.
Agam BansalCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Andrew HigginsCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Ran LeeCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Penelope RampersadCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Umesh N KhotCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Wael A JaberCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Grant W ReedCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Paul C CremerCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.
Venu MenonCleveland Clinic Heart, Vascular and Thoracic Institute, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The clinical characteristics and outcomes of patients who develop cardiogenic shock (CS) secondary to primary valvular dysfunction (valvular cardiogenic shock [VCS]) remain unclear. Objectives: The purpose of this study was to describe the cohort of patients with VCS and understand their outcomes compared to other forms of CS. Methods: All patients admitted to Cleveland Clinic cardiac intensive care unit between January 1, 2010, and December 31, 2021, with a diagnosis of CS were retrospectively identified. Characteristics and outcomes for shock patients with VCS were compared to those without VCS. Results: A total of 2,754 patients were admitted to our cardiac intensive care unit with CS, of which 442 (16%) had VCS. The median age of patients with VCS was higher than those with non-VCS (70 years vs 64 years, Conclusions: VCS is associated with poor short and long outcomes. Native valvular dysfunction and aortic valve involvement account for the majority of patients with VCS. Definitive surgical therapy and expanding the role of percutaneous therapies may be pivotal in improving clinical outcomes in this high-risk cohort.

Indexed as

cardiac critical carecardiogenic shockpercutaneous treatmentvalve replacement or repairvalvular cardiogenic shock

Identifiers

PMID39429239
PMCPMC11490668

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.