Evidence map›Paper›PMID 39429102›Full record

ArticleChemistry & biodiversity2025

Water-Soluble Curcumin Derivatives Including Aza-Crown Ether Macrocycles as Enhancers of Their Cytotoxic Activity.

Antonino Arenaza-Corona, Paola Sánchez-Portillo, Lucero González-Sebastián, Arturo Sánchez-Mora, Brian Monroy-Torres, Teresa Ramírez-Apan, Nicolás Puentes-Díaz, Jorge Alí-Torres, Victor Barba, Viviana Reyes-Marquez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antonino Arenaza-CoronaInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico.ORCID https://orcid.org/0000-0002-2971-0378
Paola Sánchez-PortilloCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos, C. P. 62209, Mexico.ORCID https://orcid.org/0009-0009-2638-0324
Lucero González-SebastiánUniversidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco No. 186, Ciudad de México, C.P. 09340, México.ORCID https://orcid.org/0000-0002-8842-7003
Arturo Sánchez-MoraInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico.ORCID https://orcid.org/0009-0009-7316-4018
Brian Monroy-TorresInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico.ORCID https://orcid.org/0000-0002-3409-504X
Teresa Ramírez-ApanInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico.
Nicolás Puentes-DíazDepartamento de Química, Universidad Nacional de Colombia- Sede Bogotá, Bogotá, 111321, Colombia.ORCID https://orcid.org/0000-0002-4638-229X
Jorge Alí-TorresDepartamento de Química, Universidad Nacional de Colombia- Sede Bogotá, Bogotá, 111321, Colombia.ORCID https://orcid.org/0000-0003-1354-8713
Victor BarbaCentro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, Morelos, C. P. 62209, Mexico.ORCID https://orcid.org/0000-0002-4913-5008
Viviana Reyes-MarquezDepartamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales s/n, Hermosillo, Sonora, C.P. 83000, Mexico.ORCID https://orcid.org/0000-0002-6646-0224
David Morales-MoralesInstituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City, C.P. 04510, Mexico.ORCID https://orcid.org/0000-0002-7984-1819

Funding

CONAHCYT A1-S-033933Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México PAPIIT IN223323PAPIIT-DGAPA-UNAM CONACYT A1-S-033933PAPIIT-DGAPA-UNAM PAPIIT IN223323
6 · The paper itself

Abstract

The synthesis of three novel curcumin derivative compounds, featuring aza-crown ether macrocycles of various sizes (aza-12-crown-4, aza-15-crown-5, and aza-18-crown-6), is described. The incorporation of these aza-crown macrocycles significantly enhances their water solubility, positioning them as groundbreaking instances of curcumin derivatives that are fully soluble in aqueous environments. These curcumin ligands (L1, L2, and L3) were then reacted with zinc acetate to afford the coordination metal complexes (L1-Zn, L2-Zn, and L3-Zn). Comprehensive characterization of all compounds was achieved using various analytical techniques, including 1D and 2D NMR spectroscopy, ATR-FTIR spectroscopy, mass spectrometry (ESI

Indexed as

Antineoplastic AgentsCell ProliferationCrown EthersCurcuminDrug Screening Assays, AntitumorSolubilityWaterAza CompoundsCell Line, TumorCoordination ComplexesDose-Response Relationship, DrugHumansMacrocyclic CompoundsMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsAza CompoundsCoordination ComplexesCrown EthersCurcuminMacrocyclic CompoundsWaterAntiproliferative activityCrown ether metallodrugsCurcumin zinc complexesMolecular dockingWater-soluble curcumin derivatives

Identifiers

PMID39429102
PMCPMC11908749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.