Evidence map›Paper›PMID 39428960›Full record

ReviewNursing open2024

Mutated Adenovirus Attacks in West Bengal, India: Risk Evaluation of Multi-Country Outbreaks and Mitigation Strategies.

Md Ashrafur Rahman, Sydney Cronmiller, Julianne Ernest, Jonah Nguyen, Donovan Zong, Rob Davis, Amanda Rawa, Marie Roke Thomas, Rana Al Mosharrafa, Yeasna Shanjana and 1 more

Abstract readReview
In one paragraph

Review in Nursing open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Md Ashrafur RahmanNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Sydney CronmillerNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Julianne ErnestNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.ORCID 0009-0001-7335-5166
Jonah NguyenNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.ORCID 0009-0005-9542-327X
Donovan ZongNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Rob DavisNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Amanda RawaNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Marie Roke ThomasNesbitt School of Pharmacy Wilkes University, Wilkes-Barre, Pennsylvania, USA.
Rana Al MosharrafaDepartment of Business Administration, Faculty of Business Studies, Prime University, Dhaka, Bangladesh.
Yeasna ShanjanaDepartment of Environmental Sciences, North South University, Bashundhara, Dhaka, Bangladesh.
Md Rabiul IslamSchool of Pharmacy, BRAC University, Dhaka, Bangladesh.ORCID 0000-0003-2820-3144

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe human adenovirus (HAdV) is beginning to spread rapidly in children through human, surface and animal vectors. Around 12,000 cases were recognised in 2022 in West Bengal and a shocking number of cases arose throughout India and in other under-developed areas. This is going to be a big threat to public health since no vaccine, awareness or protocol policies were introduced. Early detection, immediate isolation and proper policy developments are the key factors in overcoming the situation. Therefore, we performed this rapid review and discussed probable mitigation strategies, updated research on vaccine development, and treatment strategies to control the outbreaks of mutated HAdV.

designThis is a narrative review of publicly available information.

methodsHere, we extracted updated information and data using the terms HAdV outbreaks, mutations, species, risks and prevention from Google Scholar and PubMed. We considered relevant articles that have discussed prevention strategies, ongoing research, and antiviral drugs for managing HAdV outbreaks.

resultsEarly detection from throat swabs, isolation and symptomatic treatments are required to minimise viral infections. A massive test needs to be performed to find the affected people. The cases should be immediately isolated. It is recommended to treat high-touch surfaces with heat- or bleach-containing cleaners to prevent the spread of infection. Oxygen support and many broad-spectrum antivirals have been used to treat HAdV. Several studies showed antibody neutralisation and interactions between the natural killer cell receptor KIR3DS1 and HLA-F in infected cells, indicating possible therapeutic options in the future. HAdV-4 and HAdV-7 vaccines have been limitedly approved for administration to military personnel.

conclusionIsolation, certain safety measures, broad-spectrum antiviral drugs and further research on new vaccines could be useful to prevent this virus from producing a worldwide pandemic. Also, the authorities should ensure the proper therapeutic interventions and nursing care facilities for the infected children. PATIENT OR PUBLIC CONTRIBUTION: Patient or public contribution was not relevant to our work.

Indexed as

Disease OutbreaksAdenoviruses, HumanAdenovirus Infections, HumanHumansIndiaMutationRisk AssessmentAdenoviridae infectionsadenovirusdisease outbreaksepidemiologynursing

Identifiers

PMID39428960
PMCPMC11491688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.