ArticleJournal of sleep research2025
Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence.
Article in Journal of sleep research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Deep Learning-Based Assessment of Sleepiness from Fingertip Pulse Wave Analysis During Objective Daytime Testing.Annals of biomedical engineering · 2026Article
- Analysis of the correlation between the degree of sleepiness and the therapeutic effect in patients with insomnia disorder treated with digital cognitive behavioral therapy.Frontiers in psychiatry · 2026Article
- Dimensionality and reliability of the Epworth Sleepiness Scale in dental patients referred for oral appliance therapy.Journal of oral & facial pain and headache · 2025Article
- Present and Future of Central Disorders of Hypersomnolence.Journal of sleep research · 2025Review
- Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence.Journal of sleep research · 2025Article
- Dissociation of subjective and physiological stress responses in orexin-deficient narcolepsy.Sleep · 2025Article
Corrections and comments
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Authors and funding
32 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to examine gender and age-specific effects on subjective daytime sleepiness (as measured by the Epworth Sleepiness Scale), body weight and eating behaviour in patients with central disorders of hypersomnolence. Based on the European Narcolepsy Network database, we compared 1035 patients with narcolepsy type I and 505 patients with other central disorders of hypersomnolence ("narcoleptic borderland"), including narcolepsy type II (N = 308) and idiopathic hypersomnia (N = 174), using logistic regression and general linear models. In the entire study population, the Epworth Sleepiness Scale was higher in women (N = 735, mean age = 30 years, mean Epworth Sleepiness Scale = 16.6 ± SD 3.9) than in men (N = 805, mean age = 32 years, mean Epworth Sleepiness Scale = 15.8 ± SD 4.4). In women with narcolepsy type I (N = 475), both Epworth Sleepiness Scale and body mass index increased in parallel with age. In women of the narcoleptic borderland (N = 260), the Epworth Sleepiness Scale markedly peaked in their early 30s, while body mass index only started to rise at that age. This rise in body mass index following the Epworth Sleepiness Scale peak cannot be explained by sleepiness-induced uncontrolled eating, as self-reported uncontrolled eating was negatively associated with the Epworth Sleepiness Scale in this group. We propose that the narcoleptic borderland harbours a unique cluster of women in their fertile years with an unexplored aetiology requiring further investigation towards tailored interventions.
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