Evidence map›Paper›PMID 39428885›Full record

Trial reportPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2024

Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD.

Steve Lukito, Sheut-Ling Lam, Marion Criaud, Samuel Westwood, Olivia S Kowalczyk, Sarah Curran, Nadia Barrett, Christopher Abbott, Holan Liang, Emily Simonoff and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Pooled it
  2. Pooled it
  3. Effects of fMRI neurofeedback of right inferior frontal cortex on inhibitory brain activation in children with ADHD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Trial
  4. Article
  5. Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Steve LukitoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology & Neuroscience, King's College London , London, UK.ORCID 0000-0002-0616-5055
Sheut-Ling LamDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology & Neuroscience, King's College London , London, UK.ORCID 0000-0003-1065-561X
Marion CriaudDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology & Neuroscience, King's College London , London, UK.ORCID 0000-0002-9713-3568
Samuel WestwoodDepartment of Psychology, Institute of Psychiatry Psychology and Neuroscience, King's College London , London, UK.ORCID 0000-0002-0107-6651
Olivia S KowalczykDepartment of Neuroimaging, Institute of Psychiatry Psychology and Neuroscience, King's College London , London, UK.ORCID 0000-0002-6543-290X
Sarah CurranSouth London and Maudsley NHS Foundation Trust , London, UK.ORCID 0000-0002-6909-9032
Nadia BarrettSouth London and Maudsley NHS Foundation Trust , London, UK.
Christopher AbbottTavistock and Portman NHS Foundation Trust , London, UK.
Holan LiangGreat Ormond Street Hospital for Children NHS Foundation Trust , London, UK.ORCID 0000-0001-6650-9449
Emily SimonoffDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology & Neuroscience, King's College London , London, UK.ORCID 0000-0002-5450-0823
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry Psychology and Neuroscience, King's College London , London, UK.ORCID 0000-0002-5214-7421
Vincent GiampietroDepartment of Neuroimaging, Institute of Psychiatry Psychology and Neuroscience, King's College London , London, UK.ORCID 0000-0002-9381-8201
Katya RubiaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry Psychology & Neuroscience, King's College London , London, UK.ORCID 0000-0002-1410-7701

Funding

Medical Research CouncilMRC Medical Research Council and NIHR National Institute of Health Research NIHR130077MRC Medical Research Council and NIHR National Institute of Health Research NIHR2036840
6 · The paper itself

Abstract

We aimed to replicate previous effects of functional magnetic resonance imaging neurofeedback (fMRI-NF) in right inferior frontal cortex (rIFC) on IFC activation during a Stop Task in a larger group of boys with attention-deficit/hyperactivity disorder (ADHD). The present double-blind, randomized controlled trial tested the effects of 15 runs of active versus sham fMRI-NF of rIFC on performance and activation associated with successful and failed inhibition versus Go trials during a tracking Stop task in 88 boys with ADHD (44 active; 44 sham), controlling for age and medication status. No significant group-by-time interaction effects were observed for performance or brain activation during the successful stop trials, and post hoc analysis showed very low numbers of active fMRI-NF learners. Nevertheless, during error monitoring, there was a significant group-by-time interaction effect on post-error reaction time slowing and in left IFC activation, which were both increased after active compared to sham fMRI-NF. The findings are in line with our previous observation of left IFC upregulation after fMRI-NF of rIFC relative to active fMRI-NF of parahippocampal gyrus. This highlights the potentially wider regional effects that fMRI-NF of a particular self-control target region has on other self-regulatory regions in ADHD. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.

Indexed as

Attention Deficit Disorder with HyperactivityMagnetic Resonance ImagingNeurofeedbackAdolescentChildDouble-Blind MethodFrontal LobeHumansMalePrefrontal CortexADHDchildrenfMRI neurofeedbackinhibitionstop-signal task

Identifiers

PMID39428885
PMCPMC11491852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.