Evidence map›Paper›PMID 39428863›Full record

Trial reportCancer2025

Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE): A randomized controlled trial.

Jennifer Brunet, Sitara Sharma, Kendra Zadravec, Monica Taljaard, Nathalie LeVasseur, Amirrtha Srikanthan, Kelcey A Bland, Elham Sabri, Barbara Collins, Sherri Hayden and 3 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
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  4. Methodology of analysis of cognitive impairment in longitudinal randomized clinical trials in oncology: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jennifer BrunetSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0003-3242-5444
Sitara SharmaSchool of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0001-6716-7401
Kendra ZadravecRehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Monica TaljaardClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Nathalie LeVasseurBritish Columbia Cancer-Vancouver, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-2581-4903
Amirrtha SrikanthanDepartment of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0002-8903-0040
Kelcey A BlandDepartment of Physical Therapy, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Elham SabriClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Barbara CollinsSchool of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Sherri HaydenDivision of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Christine SimmonsBritish Columbia Cancer-Vancouver, Vancouver, British Columbia, Canada.
Andra M SmithSchool of Psychology, Faculty of Social Sciences, University of Ottawa, Ottawa, Ontario, Canada.
Kristin L CampbellRehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-2266-1382

Funding

Avon Foundation for WomenCanadian Cancer Society Research Institute 705382
6 · The paper itself

Abstract

backgroundAs the prevalence of chemotherapy-related cognitive impairment rises, investigation into treatment options is critical. The objectives of this study were to test the effects of an aerobic exercise intervention initiated during chemotherapy compared to usual care (wait list control condition) on (1) objectively measured cognitive function and self-reported cognitive function, as well as on (2) the impact of cognitive impairment on quality of life (QOL) postintervention (commensurate with chemotherapy completion).

methodsThe Aerobic exercise and CogniTIVe functioning in women with breAsT cancEr (ACTIVATE) trial was a two-arm, two-center randomized controlled trial conducted in Ottawa and Vancouver (Canada). Fifty-seven women (M

resultsAlthough no significant differences between groups were found for objective cognitive function outcomes postintervention after accounting for multiple testing, four of six self-reported cognitive function outcomes showed significant differences favoring the aerobic exercise group.

conclusionsAmong women initiating chemotherapy for breast cancer, aerobic exercise did not result in significant differences in objective cognitive function postintervention after chemotherapy completion; however, the results do support the use of this intervention for improving self-reported cognitive function and its impact on QOL.

Indexed as

Breast NeoplasmsCognitionExerciseQuality of LifeAdultExercise TherapyFemaleHumansMiddle AgedNeuropsychological Testsbreast neoplasmcognitionexerciseoncologyrandomized controlled trial

Identifiers

PMID39428863
PMCPMC11694240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.