Evidence map›Paper›PMID 39428758›Full record

ArticleGut microbes

Species- and subspecies-level characterization of health-associated bacterial consortia that colonize the human gut during infancy.

Samuel S Minot, Koshlan Mayer-Blackwell, Andrew Fiore-Gartland, Andrew Johnson, Steven Self, Parveen Bhatti, Lena Yao, Lili Liu, Xin Sun, Yi Jinfa and 1 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Samuel S MinotData Core, Fred Hutchinson Cancer Center, Seattle, USA.
Koshlan Mayer-BlackwellVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.
Andrew Fiore-GartlandVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.
Andrew JohnsonVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.
Steven SelfVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.
Parveen BhattiCancer Control Research, BC Cancer Research Institute, Vancouver, BC, Canada.
Lena YaoVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.
Lili LiuKey Laboratory of Occupational Disease Prevention and Treatment, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China.
Xin SunNational Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.
Yi JinfaDepartment of Pediatrics, Nanhai Maternity and Child Healthcare Hospital of Foshan, Foshan, China.
James KublinVaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, USA.ORCID 0000-0003-1279-3741

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Role of the microbiome in HIV vaccine induced heterogeneityR01AI127100 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KUBLIN, JAMES G. · 2016 to 2020
$3.6M
NIAID NIH HHS R01 AI127100NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

backgroundThe human gut microbiome develops rapidly during infancy, a key window of development coinciding with the maturation of the adaptive immune system. However, little is known about the microbiome growth dynamics over the first few months of life and whether there are any generalizable patterns across human populations. We performed metagenomic sequencing on stool samples (

resultsStrain-level

conclusionBy augmenting published metagenomic datasets with data from a newly established cohort, we were able to identify novel groups of organisms that are correlated with measures of robust human development. We hypothesize that the presence of these groups may impact human health in aggregate in ways that individual species may not in isolation.

Indexed as

BacteriaFecesGastrointestinal MicrobiomeCohort StudiesCystic FibrosisFemaleHumansInfantInfant, NewbornMaleMetagenomeMetagenomicsMicrobial Consortiabacterial consortiahuman developmentMetagenomicsMicrobiome

Identifiers

PMID39428758
PMCPMC11497992

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.