Evidence map›Paper›PMID 39428680›Full record

ArticleMagnetic resonance in medicine2025

First in-vivo magic angle directional imaging using dedicated low-field MRI.

Mihailo Ristic, Karyn E Chappell, Harry Lanz, John McGinley, Chinmay Gupte, Dimitris Amiras

Abstract read
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In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mihailo RisticDepartment of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, UK.ORCID 0000-0003-4837-9518
Karyn E ChappellDepartment of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, UK.ORCID 0000-0002-6196-4909
Harry LanzDepartment of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, UK.
John McGinleyDepartment of Mechanical Engineering, Faculty of Engineering, Imperial College London, London, UK.
Chinmay GupteDepartment of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Dimitris AmirasDepartment of Radiology, Imperial College NHS Healthcare Trust, London, UK.

Funding

The Wellcome Trust 215908/Z/19/ZWellcome Trust
6 · The paper itself

Abstract

purposeTo report the first in-vivo results from exploiting the magic angle effect, using a dedicated low-field MRI scanner that can be rotated about two axes. The magic angle directional imaging (MADI) method is used to depict collagen microstructures with 3D collagen tractography of knee ligaments and the meniscus.

methodsA novel low-field MRI system was developed, based on a transverse field open magnet, where the magnet can be rotated about two orthogonal axes. Sets of volume scans at various orientations were obtained in healthy volunteers. The experiments focused on the anterior cruciate ligament (ACL) and the meniscus of the knee. The images were co-registered, anatomical regions of interest (ROIs) were selected and the collagen fiber orientations in each voxel were estimated from the observed image intensity variations. The 3D collagen tractography was superimposed on conventional volume images.

resultsThe MADI method was successfully employed for the first time producing in-vivo results comparable to those previously reported for excised animal specimens using conventional MRI. Tractography plots were generated for the ACL and the menisci. These results are consistent with the known microstructure of collagen fibers in these tissues.

conclusionImages obtained using low-field MRI with 1 mm

Indexed as

Anterior Cruciate LigamentMagnetic Resonance ImagingAdultCollagenDiffusion Tensor ImagingEquipment DesignFemaleHumansImage EnhancementImaging, Three-DimensionalKnee JointMaleMeniscusReproducibility of ResultsSensitivity and SpecificityCollagencollagenmagic angle effectmusculoskeletal imaging

Identifiers

PMID39428680
PMCPMC11680723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.